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4'- deaza- 1'- aza- 2'- deoxy- 1'- (9- methylene)immucillin G

structure in first source

Also Known As:

DADMe-ImmG; DADMe-immucillin G

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G: 3
  - Ribonucleosides: 49
    - Adenosine: 12431
      - 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G: 3

Experts

1.	Schramm, Vern L: 3 articles (01/2021 - 01/2018)
2.	Harijan, Rajesh K: 2 articles (01/2021 - 01/2018)
3.	Minnow, Yacoba V T: 1 article (01/2021)
4.	Daily, Johanna P: 1 article (01/2018)
5.	Ducati, Rodrigo G: 1 article (01/2018)
6.	Evans, Gary B: 1 article (01/2018)
7.	Fajardo, J Eduardo: 1 article (01/2018)
8.	Fiser, Andras: 1 article (01/2018)
9.	Namanja-Magliano, Hilda A: 1 article (01/2018)
10.	Tyler, Peter C: 1 article (01/2018)

Related Diseases

1.	Malaria 01/01/2021 - "4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-G (DADMe-ImmG) is a transition state analog inhibitor of this enzyme, and P. falciparum infections in an Aotus primate malaria model can be cleared by oral administration of DADMe-ImmG. " 01/01/2018 - "First, DADMe-Immucillin-G is a purine nucleoside phosphorylase (PNP) inhibitor that blocks purine salvage and shows clinical potential for treatment for the malaria parasite Plasmodium falciparum, a purine auxotroph requiring hypoxanthine for purine nucleotide synthesis. "
2.	Infections 01/01/2021 - "4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-G (DADMe-ImmG) is a transition state analog inhibitor of this enzyme, and P. falciparum infections in an Aotus primate malaria model can be cleared by oral administration of DADMe-ImmG. " 01/01/2018 - "falciparum purine nucleoside phosphorylase (PfPNP) by DADMe-Immucillin-G (DADMe-ImmG) causes purine starvation and parasite death in vitro and in primate infection models. "
3.	Starvation 01/01/2018 - "Both point mutations and gene amplification are required to overcome purine starvation induced by DADMe-ImmG. " 01/01/2018 - "falciparum purine nucleoside phosphorylase (PfPNP) by DADMe-Immucillin-G (DADMe-ImmG) causes purine starvation and parasite death in vitro and in primate infection models. "

Related Drugs and Biologics

1.	Enzymes
2.	Purine-Nucleoside Phosphorylase
3.	4'- deaza- 1'- aza- 2'- deoxy- 1'- (9- methylene)immucillin G
4.	purine
5.	Hypoxanthine
6.	Nucleotides

Related Therapies and Procedures

1.	Oral Administration