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carglumic acid

carglumic acid could be helpful in lowering plasma ammonia levels over 400 micromol/L more rapidly

Also Known As:

Carbaglu

Networked: 35 relevant articles (1 outcomes, 1 trials/studies)

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Drug Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - carglumic acid: 35
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - carglumic acid: 35

Experts

1.	Ababneh, Faroug: 2 articles (10/2021 - 01/2019)
2.	Ahmed, Hind: 2 articles (10/2021 - 01/2019)
3.	Al Mutairi, Fuad: 2 articles (10/2021 - 01/2019)
4.	Alasmari, Ali: 2 articles (10/2021 - 01/2019)
5.	Alfadhel, Majid: 2 articles (10/2021 - 01/2019)
6.	Aljeraisy, Majed: 2 articles (10/2021 - 01/2019)
7.	Alohali, Lina: 2 articles (10/2021 - 01/2019)
8.	Alswaid, Abdulrahman: 2 articles (10/2021 - 01/2019)
9.	Elamin, Mohammed: 2 articles (10/2021 - 01/2019)
10.	Eyaid, Wafaa: 2 articles (10/2021 - 01/2019)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2015 - "These findings suggest that carglumic acid may serve as a safe and effective therapeutic to treat both TNBC and pancreatic cancer. "
2.	Propionic Acidemia 01/01/2019 - "Evaluation of long-term effectiveness of the use of carglumic acid in patients with propionic acidemia (PA) or methylmalonic acidemia (MMA): study protocol for a randomized controlled trial." 01/01/2022 - "Long-term use of carglumic acid in methylmalonic aciduria, propionic aciduria and isovaleric aciduria in Italy: a qualitative survey." 10/11/2021 - "Long-term effectiveness of carglumic acid in patients with propionic acidemia (PA) and methylmalonic acidemia (MMA): a randomized clinical trial." 01/01/2020 - "Carglumic Acid Contributes to a Favorable Clinical Course in a Case of Severe Propionic Acidemia." 01/30/2008 - "Hyperammonemia in patients with methylmalonic aciduria (MMA) and propionic aciduria (PA) is caused by accumulation of propionyl-CoA which decreases the synthesis of N-acetyl-glutamate, the natural activator of carbamyl phosphate synthetase 1. A treatment approach with carglumic acid, the structural analogue of N-acetyl-glutamate, has been proposed to decrease high ammonia levels encountered in MMA and PA crises. "
3.	Methylmalonic acidemia 09/01/2022 - "Carglumic acid in methylmalonic acidemia: Use of breast milk as an alternative vehicle to water." 01/01/2019 - "Evaluation of long-term effectiveness of the use of carglumic acid in patients with propionic acidemia (PA) or methylmalonic acidemia (MMA): study protocol for a randomized controlled trial." 01/01/2022 - "Long-term use of carglumic acid in methylmalonic aciduria, propionic aciduria and isovaleric aciduria in Italy: a qualitative survey." 10/11/2021 - "Long-term effectiveness of carglumic acid in patients with propionic acidemia (PA) and methylmalonic acidemia (MMA): a randomized clinical trial." 01/30/2008 - "Hyperammonemia in patients with methylmalonic aciduria (MMA) and propionic aciduria (PA) is caused by accumulation of propionyl-CoA which decreases the synthesis of N-acetyl-glutamate, the natural activator of carbamyl phosphate synthetase 1. A treatment approach with carglumic acid, the structural analogue of N-acetyl-glutamate, has been proposed to decrease high ammonia levels encountered in MMA and PA crises. "
4.	Hyperammonemia 06/01/2022 - "The hyperammonemia was corrected in 15 h and with the continued use of carglumic acid for 3 days, there was no rebound of hyperammonemia. " 10/11/2021 - "Using carglumic acid in addition to standard treatment over the long term significantly reduces the number of ER admissions because of hyperammonemia in patients with PA and MMA." 09/01/2020 - "We report a retrospective study of 25 pediatric patients, (15 females [60%]; age: 7.6 ± 4.9 years), with different underlying disorders, who suffered from hyperammonemia due to VPA and who were treated with carglumic acid (CA). " 01/01/2020 - "The patient did not develop hyperammonemia after receiving carglumic acid and was never hospitalized. " 01/01/2015 - "Our data from in vivo models indicates that orally taking 10% of the carglumic acid dose currently used for the treatment of hyperammonemia ise ffective to suppress the growth of pancreatic ductal adenocarcinomaand TNBC. "
5.	Brain Diseases (Brain Disorder) 11/01/2017 - "Carglumic acid must be considered an important part of the treatment in adult patients with hyperammonaemic encephalopathy due to VPA, although a randomised clinical trial needs to be conducted with the drug in order to test its efficacy. " 11/01/2017 - "We report the cases of two adult patients with encephalopathy due to VPA who were treated with carglumic acid, in addition to the conventional measures. " 10/01/2014 - "Hyperammonemic encephalopathy in an adenocarcinoma patient managed with carglumic acid." 01/01/2020 - "Overall, there was a strong negative correlation between plasma ammonia levels and carglumic acid levels (r = -0.86, p = 0.0013), and recurrence of hyperammonemic encephalopathy was not observed while the patients were taking carglumic acid." 01/01/2018 - "[Treatment of encephalopathy by means of valproic acid with carglumic acid. "

Related Drugs and Biologics

1.	Valproic Acid (Depakote)
2.	N-acetyl glutamate synthetase deficiency
3.	Ammonia
4.	Carbamyl Phosphate (Carbamoyl Phosphate)
5.	Glutamic Acid (Glutamate)
6.	Ligases (Synthetase)
7.	Glutamine (L-Glutamine)
8.	carglumic acid
9.	Esomeprazole (Nexium)
10.	Amino-Acid N-Acetyltransferase (N-Acetylglutamate Synthase)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation