|1.||Jiang, Sheng: 5 articles (10/2014 - 03/2010)|
|2.||Luesch, Hendrik: 4 articles (03/2015 - 11/2010)|
|3.||Williams, Robert M: 3 articles (04/2015 - 08/2008)|
|4.||Hong, Jiyong: 3 articles (08/2014 - 11/2010)|
|5.||Clausen, Dane J: 2 articles (04/2015 - 03/2015)|
|6.||Bradner, James E: 2 articles (04/2015 - 08/2008)|
|7.||Christianson, David W: 2 articles (03/2015 - 08/2011)|
|8.||Salvador, Lilibeth A: 2 articles (08/2014 - 11/2010)|
|9.||Liu, Yanxia: 2 articles (08/2014 - 11/2010)|
|10.||Bhansali, Pravin: 2 articles (07/2013 - 11/2011)|
09/01/2014 - "This review focuses on marine natural compounds with epigenetic activities and their synthetic derivatives displaying anti-cancer properties including largazole, psammaplins, trichostatins and azumamides. "
08/14/2014 - "The in vitro effects of largazole analogues on cancer cell proliferation and enzymatic activities of purified HDACs were comparable to the natural product. "
01/01/2014 - "Therefore, current antitumor drug design often targets HDACs, inhibiting overexpressed HDAC in tumor cells with natural or synthesized small molecules like largazole. "
04/01/2012 - "The intriguing structure and biological activity of largazole have attracted strong interest from the synthetic chemistry community to establish synthetic routes to largazole and to investigate its potential as a cancer therapeutic. "
01/01/2011 - "Largazole, isolated from the marine cyanobacterium Symploca sp. has exhibited potent inhibitory activity against many cancer cell lines. "
10/05/2014 - "In this study, we examined the effect of largazole, an inhibitor of class I HDACs, on inflammatory corneal angiogenesis. "
10/05/2014 - "In a mouse model of alkali-induced corneal neovascularization (CNV), topical application of largazole to the injured corneas attenuated CNV. "
10/05/2014 - "Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization."
|3.||Pancreatic Neoplasms (Pancreatic Cancer)
04/01/2015 - "In vitro studies in colon, lung, and pancreatic cancer cell lines showed that pyridyl-substituted Largazole analogs had low-nanomolar/high-picomolar antiproliferative activity, and induced apoptosis and cell cycle arrest at concentrations equivalent to or lower than the parent compound Largazole. "
|4.||Lung Neoplasms (Lung Cancer)
10/10/2013 - "In this study, we test the effects of a natural macrocyclic depsipeptide largazole on lung cancer cells and report that this compound potently inhibits the proliferation and clonogenic activity of lung cancer cells but not normal bronchial epithelial cells. "
10/10/2013 - "Interestingly, largazole enhances the E2F1-HDAC1 binding affinity and induces a proteasomal degradation of E2F1, leading to suppression of E2F1 function in lung cancer but not normal bronchial epithelial cells. "
10/10/2013 - "Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells."
10/10/2013 - "Because E2F1 is overexpressed in lung cancer tumor samples, these data indicate that largazole is an E2F1-targeting cell cycle inhibitor, which bears therapeutic potentials for this malignant neoplasm. "
|5.||Liver Cirrhosis (Hepatic Cirrhosis)
04/01/2013 - "This study investigated the effects of largazole against liver fibrosis. "
04/01/2013 - "Our findings revealed a novel role of largazole in the treatment of liver fibrosis. "
04/01/2013 - "A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling."
|1.||Histone Deacetylases (Histone Deacetylase)
|4.||Histone Deacetylase Inhibitors
|8.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|9.||Tissue Inhibitor of Metalloproteinase-1
|10.||Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)