centanamycin

a potent antimalarial and transmission-blocking DNA-binding agent inspired from ( )-duocarmycin SA that lacks a stereocenter; structure in first source

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lee, Moses: 2 articles (03/2008 - 02/2008)
2.	Purcell, Lisa A: 2 articles (03/2008 - 02/2008)
3.	Rodriguez, Ana: 2 articles (03/2008 - 02/2008)
4.	Spithill, Terry W: 2 articles (03/2008 - 02/2008)
5.	Yanow, Stephanie K: 2 articles (03/2008 - 02/2008)
6.	Pradel, Gabriele: 1 article (02/2008)
7.	Sato, Atsushi: 1 article (02/2008)

Related Diseases

1.	Infections 02/15/2008 - "We show here that the compound centanamycin is very effective against blood-stage malarial infections in vitro and in vivo and has profound effects on sexual differentiation of the parasites in mosquitoes. " 03/01/2008 - "Inoculation of mice with sporozoites that were treated in vitro with centanamycin failed to produce blood stage infections. "
2.	Parasitemia 03/01/2008 - "Sporozoites were treated with the DNA sequence-specific alkylating agent centanamycin, a compound that significantly affects blood stage parasitemia and transmission of murine malaria and also inhibits Plasmodium falciparum growth in vitro. "
3.	Malaria 03/01/2008 - "Sporozoites were treated with the DNA sequence-specific alkylating agent centanamycin, a compound that significantly affects blood stage parasitemia and transmission of murine malaria and also inhibits Plasmodium falciparum growth in vitro. "

Related Drugs and Biologics

1.	Alkylating Agents