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diapocynin

synthesized by oxidative coupling of two apocynin monomers and is 13 times more lipophilic than apocynin; structure in first source

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Acetophenones: 16
    - diapocynin: 8
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        diapocynin: 8

Experts

1.	Dranka, Brian P: 3 articles (11/2014 - 10/2012)
2.	Joseph, Joy: 3 articles (11/2014 - 10/2012)
3.	Kalyanaraman, Balaraman: 3 articles (11/2014 - 10/2012)
4.	Kanthasamy, Anumantha G: 3 articles (11/2014 - 10/2012)
5.	Ibrahim, Weam W: 2 articles (10/2022 - 01/2020)
6.	Ismail, Hesham M: 2 articles (01/2020 - 01/2014)
7.	Gifford, Alison: 2 articles (11/2014 - 08/2013)
8.	Zielonka, Jacek: 2 articles (11/2014 - 08/2013)
9.	Ghosh, Anamitra: 2 articles (08/2013 - 10/2012)
10.	Abdel Rasheed, Nora O: 1 article (10/2022)

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy) 01/01/2014 - "These findings support the central role played by NOX-ROS in the pathogenic cascade leading to muscular dystrophy and suggest diapocynin as an effective NOX inhibitor that might be helpful for future therapeutic approaches. "
2.	Ulcerative Colitis 05/24/2017 - "In this study, diapocynin has been chemically synthesized and its activity on several inflammatory mediators in LPS-stimulated RAW 264.7 macrophages and its anti-inflammatory effect on ulcerative colitis induced by dextran sodium sulfate (DSS) in mice analyzed. "
3.	Parkinson Disease (Parkinson's Disease) 11/07/2014 - "We hypothesized that the increased mitochondrial permeability of Mito-apocynin, due to the triphenylphosphonium moiety, would allow improvement of Parkinson's disease (PD) symptoms at lower doses than those required for diapocynin. " 08/09/2013 - "Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse."
4.	Cognitive Dysfunction 01/01/2020 - "Hence, the current work is dedicated to investigate the influence of diapocynin on cognitive impairment prompted by ovariectomy combined with D-galactose injection in rats (an AD animal model), and to elucidate the signaling mechanisms regulating diapocynin-induced effects. "
5.	Disease Progression 10/23/2012 - "Diapocynin also halted the disease progression in a chronic mouse model of PD. "

Related Drugs and Biologics

1.	Dextrans (Dextran)
2.	sodium sulfate (sodium bisulfate)
3.	acetovanillone (apocynin)
4.	Sirtuin 1
5.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6.	Neuroprotective Agents
7.	Prodrugs
8.	Phosphotransferases (Kinase)
9.	Leucine (L-Leucine)
10.	Glial Fibrillary Acidic Protein

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Oral Administration