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Pt(O,O'-acac)(gamma-acac)(DMS)

DMS - dimethylsulfide

Also Known As:

PtAcacDMS

Networked: 6 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - Pt(O,O'-acac)(gamma-acac)(DMS): 6

Experts

1.	De Pascali, Sandra Angelica: 3 articles (04/2021 - 07/2010)
2.	Fanizzi, Francesco Paolo: 3 articles (04/2021 - 07/2010)
3.	Bernocchi, Graziella: 3 articles (01/2019 - 03/2011)
4.	Ferrari, Beatrice: 2 articles (04/2021 - 01/2019)
5.	Roda, Elisa: 2 articles (04/2021 - 01/2019)
6.	Bottone, Maria G: 2 articles (01/2019 - 03/2011)
7.	De Pascali, Sandra A: 2 articles (01/2019 - 03/2011)
8.	Fanizzi, Francesco P: 2 articles (01/2019 - 03/2011)
9.	Migoni, Danilo: 2 articles (02/2015 - 03/2011)
10.	Astesana, Valentina: 1 article (04/2021)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2021 - "Thus, based on the knowledge that several chemotherapeutics induce cancer cell death through an aberrant increase in [Ca2+]i, in the present in vitro study we compared CDDP and PtAcacDMS effects on apoptosis and intracellular Ca2+ dynamics in human glioblastoma T98G cells, applying a battery of complementary techniques, i.e., flow cytometry, immunocytochemistry, electron microscopy, Western blotting, qRT-PCR, and epifluorescent Ca2+ imaging. " 01/01/2019 - "In the present study, standard acute (48 h-exposure) and long-term effects (7 day-recovery after treatment or 7 day-recovery followed by reseeding and 96 h-growth), of cisPt and PtAcacDMS (40 and 10 μM, respectively) were investigated in vitro employing rat B50 neuroblastoma as a cancer model. " 02/01/2015 - "A new platinum compound, (Pt(O,O'-acac)(γ-acac)(DMS)) (PtAcacDMS), has been shown to possess higher cytotoxic activity than cisplatin on several cancer and chemoresistant cell lines. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "[Pt(O,O'-acac)(gamma-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway." 07/01/2010 - "Hence, [Pt(O,O'-acac)(gamma-acac)(DMS)] may be a promising therapeutic agent for preventing growth and metastasis of breast cancer." 01/01/2008 - "The objective of this study was to investigate the hypothesis that [Pt(O,O'-acac)(gamma-acac)(DMS)] is also cytotoxic in a MCF-7 breast cancer cell line relatively insensitive to cisplatin, and to gain a more detailed analysis of the cell death pathways. "
3.	Neuroblastoma 01/01/2019 - "In the present study, standard acute (48 h-exposure) and long-term effects (7 day-recovery after treatment or 7 day-recovery followed by reseeding and 96 h-growth), of cisPt and PtAcacDMS (40 and 10 μM, respectively) were investigated in vitro employing rat B50 neuroblastoma as a cancer model. "
4.	Glioblastoma (Glioblastoma Multiforme) 04/01/2021 - "Thus, based on the knowledge that several chemotherapeutics induce cancer cell death through an aberrant increase in [Ca2+]i, in the present in vitro study we compared CDDP and PtAcacDMS effects on apoptosis and intracellular Ca2+ dynamics in human glioblastoma T98G cells, applying a battery of complementary techniques, i.e., flow cytometry, immunocytochemistry, electron microscopy, Western blotting, qRT-PCR, and epifluorescent Ca2+ imaging. "
5.	Neoplasm Metastasis (Metastasis) 07/01/2010 - "Hence, [Pt(O,O'-acac)(gamma-acac)(DMS)] may be a promising therapeutic agent for preventing growth and metastasis of breast cancer." 07/01/2010 - "Sublethal concentrations of [Pt(O,O'-acac)(gamma-acac)(DMS)] induced anoikis and prevented events leading to metastasis via alterations in cell migration, anchorage independency, stromal interactions and MMP activity. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Platinum Compounds (Compounds, Platinum)
3.	Matrix Metalloproteinases (MMPs)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)