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symplocamide A

a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - symplocamide A: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - symplocamide A: 1

Experts

1.	Edwards, Daniel J: 1 article (01/2008)
2.	Gerwick, William H: 1 article (01/2008)
3.	Linington, Roger G: 1 article (01/2008)
4.	Matainaho, Teatulohi: 1 article (01/2008)
5.	McPhail, Kerry L: 1 article (01/2008)
6.	Shuman, Cynthia F: 1 article (01/2008)

Related Diseases

1.	Neuroblastoma 01/01/2008 - "The presence of several unusual structural features in symplocamide A provides new insights into the pharmacophore model for protease selectivity in this drug class and may underlie the potent cytotoxicity of this compound to H-460 lung cancer cells (IC50=40 nM) as well as neuro-2a neuroblastoma cells (IC50=29 nM)."
2.	Neoplasms (Cancer) 01/01/2008 - "Investigation of a Symploca sp. from Papua New Guinea has led to the isolation of symplocamide A (1), a potent cancer cell cytotoxin, which also inhibits serine proteases with a 200-fold greater inhibition of chymotrypsin over trypsin. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2008 - "The presence of several unusual structural features in symplocamide A provides new insights into the pharmacophore model for protease selectivity in this drug class and may underlie the potent cytotoxicity of this compound to H-460 lung cancer cells (IC50=40 nM) as well as neuro-2a neuroblastoma cells (IC50=29 nM)."

Related Drugs and Biologics

1.	Serine Proteases (Serine Protease)
2.	Trypsin
3.	Peptide Hydrolases (Proteases)
4.	Cytotoxins (Cytolysins)
5.	Chymotrypsin