methyl 2- methylsulfanyl- 5- (1- naphthyl)- 4- nitro- 2,4- pentadienoate

has antineoplastic activity; structure in first source

Also Known As:

1-Naph-NMCB

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - methyl 2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        methyl 2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - methyl 2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate: 2

Experts

1.	Aiello, Cinzia: 2 articles (12/2010 - 12/2007)
2.	Maccagno, Massimo: 2 articles (12/2010 - 12/2007)
3.	Petrillo, Giovanni: 2 articles (12/2010 - 12/2007)
4.	Spinelli, Domenico: 2 articles (12/2010 - 12/2007)
5.	Viale, Maurizio: 2 articles (12/2010 - 12/2007)
6.	Ferrini, Silvano: 1 article (12/2010)
7.	Fontana, Antonella: 1 article (12/2010)
8.	Gasbarri, Carla: 1 article (12/2010)
9.	Guernelli, Susanna: 1 article (12/2010)
10.	Rizzato, Egon: 1 article (12/2010)

Related Diseases

1.	Neoplasms (Cancer) 12/21/2010 - "On the other hand, in vitro studies with different cancer cell lines showed that the cytotoxic activity of both 1-Naph-NMCB and 1-Naph-NHCB were fully preserved and in some cases also enhanced when entrapped into liposomal carriers."
2.	Lewis Lung Carcinoma 12/01/2007 - "In order to verify in vivo our in vitro results we have tested the antitumour activity of 1-Naph-DNB and 1-Naph-NMCB in several murine tumour models, namely the myelomonocytic P388 and the Lewis lung carcinoma 3LL in BDF1 mice, the melanoma B16 in C57Bl mice, the fibrosarcoma WEHI 164 in nude mice and, finally, the C51 colon cancer in Balb/c mice. "
3.	Experimental Melanoma 12/01/2007 - "In order to verify in vivo our in vitro results we have tested the antitumour activity of 1-Naph-DNB and 1-Naph-NMCB in several murine tumour models, namely the myelomonocytic P388 and the Lewis lung carcinoma 3LL in BDF1 mice, the melanoma B16 in C57Bl mice, the fibrosarcoma WEHI 164 in nude mice and, finally, the C51 colon cancer in Balb/c mice. "
4.	Fibrosarcoma 12/01/2007 - "In order to verify in vivo our in vitro results we have tested the antitumour activity of 1-Naph-DNB and 1-Naph-NMCB in several murine tumour models, namely the myelomonocytic P388 and the Lewis lung carcinoma 3LL in BDF1 mice, the melanoma B16 in C57Bl mice, the fibrosarcoma WEHI 164 in nude mice and, finally, the C51 colon cancer in Balb/c mice. "
5.	Colonic Neoplasms (Colon Cancer) 12/01/2007 - "In order to verify in vivo our in vitro results we have tested the antitumour activity of 1-Naph-DNB and 1-Naph-NMCB in several murine tumour models, namely the myelomonocytic P388 and the Lewis lung carcinoma 3LL in BDF1 mice, the melanoma B16 in C57Bl mice, the fibrosarcoma WEHI 164 in nude mice and, finally, the C51 colon cancer in Balb/c mice. "

Related Drugs and Biologics

1.	1,4- bis(1- naphthyl)- 2,3- dinitro- 1,3- butadiene