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IB05204

inhibits angiogenesis in vitro and in vivo; structure in first source

Also Known As:

4,8-dichloro-12-phenylpyrido(5',6':4'',5'';3',2':4,5)dithieno(3'',2''-d':3,2-d)-1,2,3-ditriazine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - IB05204: 1

Experts

1.	Fernández, Antonio: 1 article (10/2007)
2.	Martínez-Poveda, Beatriz: 1 article (10/2007)
3.	Medina, Miguel-Angel: 1 article (10/2007)
4.	Muñoz-Chápuli, Ramón: 1 article (10/2007)
5.	Quesada, Ana R: 1 article (10/2007)
6.	Quintela, José M: 1 article (10/2007)
7.	Rodríguez-Nieto, Salvador: 1 article (10/2007)

Related Diseases

1.

Neoplasms (Cancer)

10/01/2007 - "Although IB05204 inhibits the growth of endothelial and tumor cells in culture, its antiangiogenic activity seems to be mainly dependent on the prevention of endothelial capillary-like tube formation and inhibition of endothelial migration because these effects are recorded at lower concentrations. "
10/01/2007 - "IB05204 treatment inhibits matrix metalloproteinase-2 (MMP-2) production in endothelial and tumor cells, down-regulates endothelial cyclooxygenase-2 expression, and represses phosphorylation of endothelial Akt in response to serum stimulation, suggesting that IB05204 interferes with molecular mechanisms of cell migration and survival. "

Related Drugs and Biologics

1.	Cyclooxygenase 2 (Cyclooxygenase-2)
2.	Matrix Metalloproteinase 2 (Gelatinase A)