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14- ethyl- 2,5,11- trimethyl- 4,13,19,20- tetraoxa- tricyclo(14.2.1.1(7,10))eicosane- 3,12- dione

a macrolide compound isolated from Streptomyces sp. Is9131, displayed wide cytotoxicity in human tumor cell lines; structure in first source

Also Known As:

MFTZ-1

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ding, Jian: 2 articles (09/2010 - 11/2007)
2.	Lin, Li-Ping: 2 articles (09/2010 - 11/2007)
3.	Miao, Ze-Hong: 2 articles (09/2010 - 11/2007)
4.	Shen, Yue-Mao: 2 articles (09/2010 - 11/2007)
5.	Dai, Mei: 1 article (09/2010)
6.	Li, Ting: 1 article (09/2010)
7.	Ren, Xuan: 1 article (09/2010)
8.	Tong, Lin-Jiang: 1 article (09/2010)
9.	Yang, Na: 1 article (09/2010)
10.	Cai, Yu-Jun: 1 article (11/2007)

Related Diseases

1.	Leukemia 11/01/2007 - "Further studies showed that MFTZ-1 induced DNA double-strand breaks and triggered mitochondria-dependent apoptosis in human leukemia HL-60 cells. "
2.	Hypoxia (Hypoxemia) 09/01/2010 - "Moreover, MFTZ-1 disrupted tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by hypoxia with low-concentration serum or by serum at normoxia, and inhibited HUVECs migration at normoxia. " 09/01/2010 - "In this study, we further examined the effects of MFTZ-1 on hypoxia-inducible factor-1α (HIF-1α) accumulation, vascular endothelial growth factor (VEGF) secretion and angiogenesis. " 09/01/2010 - "MFTZ-1 reduced HIF-1α accumulation driven by hypoxia or growth factors in human cancer cells. "
3.	Poisoning 11/01/2007 - "Together, the well-defined Topo II-poisoning function and the potent antitumor activity, with the appreciable anti-multidrug resistance action in particular, promises MFTZ-1 as a novel potential Topo II-targeted agent, which merits further research and development."
4.	Neoplasms (Cancer) 09/01/2010 - "MFTZ-1 reduced HIF-1α accumulation driven by hypoxia or growth factors in human cancer cells. "
5.	Carcinoma (Carcinomatosis) 11/01/2007 - "The in vivo experiments showed that MFTZ-1 had inhibitory effects on the human ovarian carcinoma HO-8910 cell line xenotransplanted in nude mice. "

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