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SR140333B

a neurokinin-1 receptor antagonist

Also Known As:

(S)1-(2-(3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)piperidin-3-yl)ethyl)-4-phenyl-1-azoniabicyclo(2.2.2)octane chloride

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - Tropanes: 1
      - SR140333B: 4
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Tropanes: 1
    - SR140333B: 4
- Bridged-Ring Heterocyclic Compounds
  - Tropanes: 1
    - SR140333B: 4
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - Tropanes: 1
        SR140333B: 4

Experts

1.	Barbosa, Felipe L: 1 article (04/2016)
2.	Borges, Beatriz S: 1 article (04/2016)
3.	Brito, Haissa Oliveira: 1 article (04/2016)
4.	Fraga, Daniel: 1 article (04/2016)
5.	Franco, Celia R C: 1 article (04/2016)
6.	Reis, Renata Cristiane Dos: 1 article (04/2016)
7.	Zampronio, Aleksander Roberto: 1 article (04/2016)
8.	Dong, Shouliang: 1 article (10/2015)
9.	He, Chunbo: 1 article (10/2015)
10.	Wei, Chunnan: 1 article (10/2015)

Related Diseases

1.	Hyperalgesia 06/01/2013 - "Moreover, heat, but not cold or mechanical, hyperalgesia induced by constriction of the infraorbital nerve, a model of trigeminal neuropathic pain, was abolished by pretreatment with SR140333B. " 06/01/2013 - "Systemic treatment with SR140333B (3 mg/kg) also reduced carrageenan-induced heat hyperalgesia, but did not exert any influence on carrageenan-induced cold hyperalgesia. " 06/01/2013 - "However, substance P at this latter dose induced orofacial heat hyperalgesia, which was reduced by the pre-treatment of rats with a non-peptide NK1 receptor antagonist (SR140333B, 3mg/kg). " 10/01/2015 - "EKA/B (30 pmol) only weakened 100 pmol Mpa-induced hyperalgesia at 5 min, but could enhance it during 20-30 min. However, EKA/B (100 pmol) antagonized all dose levels of Mpa significantly at 5 min and blocked them completely at 10 min. EKA/B (3 nmol) co-injected with Mpa presented marked analgesia at 5 min and enduring hyperalgesia within 20-60 min. To investigate the underlying mechanisms between Mpa and EKA/B, SR140333B and SR142801 (NK1 and NK3 receptor antagonists, respectively) were utilized. "
2.	Fever (Fevers) 04/12/2011 - "On the other hand, intracerebroventricular administration of SR140333B significantly reduced the fever induced by peripheral injection of LPS. " 04/12/2011 - "Our results show that the systemic injection of SR140333B did not modify the fever induced by LPS at a dose that is able to reduce protein extravasation induced by SP in the skin. " 04/12/2011 - "Considering that the febrile response can result from the generation of several endogenous pyrogens, among them interleukin (IL)-1β and macrophage inflammatory protein-1α (CCL3/MIP-1α), we also examined the effect of SR140333B on the fever induced by these cytokines which act through prostaglandin-dependent and -independent mechanisms, respectively. " 04/15/2016 - "Intracerebroventricular (i.c.v.) administration of the neurokinin-1 (NK1) receptor antagonist SR140333B in rats reduced fever that was induced by an i.c.v. injection of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2), corticotropin-releasing factor (CRF), endothelin-1 (ET-1), and morphine (MOR). "
3.	Neuralgia (Stump Neuralgia) 06/01/2013 - "Moreover, heat, but not cold or mechanical, hyperalgesia induced by constriction of the infraorbital nerve, a model of trigeminal neuropathic pain, was abolished by pretreatment with SR140333B. "

Related Drugs and Biologics

1.	Endothelin-1 (Endothelin 1)
2.	Cytokines
3.	Interleukin-6 (Interleukin 6)
4.	Dinoprostone (PGE2)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Substance P
7.	Pyrogens
8.	Proteins (Proteins, Gene)
9.	Prostaglandins
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Analgesia