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4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide

inhibits 11-hydroxysteroid dehydrogenase type 1; structure in first source

Also Known As:

PF 915275; PF-915275; PF915275

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - 4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide: 2

Experts

1.	Chang, Ling-Ling: 2 articles (01/2018 - 06/2016)
2.	Wang, Paulus S: 2 articles (01/2018 - 06/2016)
3.	Wun, Wan-Song Alfred: 1 article (01/2018)
4.	Wun, Wan-Song A: 1 article (06/2016)

Related Diseases

1.

Adrenocortical Hyperfunction (Adrenal Gland Hyperfunction)

01/01/2018 - "This study aimed to determine whether PF915275 could alleviate the hyperadrenalism induced by NP. "
06/01/2016 - "This study examined the effect of PF915275 (a selective 11β-HSD1 inhibitor) on hyperadrenalism and adipogenesis in male rats exposed to NP during development. "
01/01/2018 - "An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells."
06/01/2016 - "The results showed that treatment with the 11β-HSD1 inhibitor PF915275 reversed/alleviated NP-induced hyperadrenalism via the following mechanisms: (1) decreasing serum corticosterone, 11β-hydroxylase, and aldosterone synthase levels; (2) significantly increasing PPARα protein and mRNA expression. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP11B2 (CYP11B2)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Hydroxysteroid Dehydrogenases
5.	Corticosterone
6.	nonylphenol