guajadial

05/25/2019 - "The aim of this study was to evaluate the effect of guajadial on drug resistance in drug-resistant breast cancer cells. "
05/25/2019 - "These findings suggested that guajadial treatment might be a new approach to overcome the drug resistance in the chemotherapy of breast cancer."
05/25/2019 - "In conclusion, guajadial acted as an inhibitor of drug resistance, which might be mediated by the inhibition of ABC transporter expression and PI3K/Akt pathway in drug-resistant breast cancer cells. "
05/25/2019 - "Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells."

05/25/2019 - "Guajadial, a natural meroterpenoid, has been found to possess anti-tumor activity. "
09/01/2018 - "This research indicated that guajadial not only inhibited endothelial cell proliferation and migration but also suppress tumor growth in human NSCLC xenograft mouse models. "
03/27/2020 - "Guajadial, a caryophyllene-based meroterpenoid, has been studied for potential anticancer effects tested in tumor cells and animal experimental models. "
03/27/2020 - "These results suggest a relationship between anti-proliferative and anti-estrogenic activity of guajadial, which possibly acts in tumor inhibition through estrogen receptors due to the compounds structural similarity to tamoxifen."
01/01/2014 - "The ability of guajadial, psidial A and psiguadials A and B to reduce tumor growth and stimulate uterus proliferation, as well as their in silico docking similarity to tamoxifen, suggest that these compounds may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy. "