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limonexic acid

antinociceptive from Raulinoa echinata; structure in first source

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Limonins: 143
        limonexic acid: 4

Experts

1.	Patil, Bhimanagouda S: 3 articles (02/2021 - 10/2012)
2.	Jayaprakasha, Guddadarangavvanahally K: 2 articles (02/2013 - 10/2012)
3.	Kim, Jinhee: 2 articles (02/2013 - 10/2012)
4.	Chidambara Murthy, K N: 1 article (02/2021)
5.	Jayaprakasha, G K: 1 article (02/2021)
6.	Safe, Stephen: 1 article (02/2021)
7.	Vikram, Amit: 1 article (10/2012)
8.	Biavatti, Maique W: 1 article (11/2007)
9.	Burger, Cristiani: 1 article (11/2007)
10.	De Souza, Márcia Maria: 1 article (11/2007)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 02/15/2021 - "In this study, limonin, nomilin and limonexic acid (LNA) were investigated for understanding the possible mode of cytotoxicity in cultured pancreatic cancer (Panc-28) cells. "
2.	Colonic Neoplasms (Colon Cancer) 10/01/2012 - "In the present study, limonoids, including methyl nomilinate, isoobacunoic acid, isolimonexic acid (ILNA), and limonexic acid (LNA), were purified, identified by LC-MS and NMR spectral data and evaluated for their biological effects on SW480 human colon adenocarcinoma cells. "
3.	Pain (Aches) 11/01/2007 - "The antinociceptive effect of the limonexic acid isolate of Raulinoa echinata Cowan in four models of pain in mice is described. " 11/01/2007 - "In the formalin test, limonexic acid inhibited both the first and second phases of formalin-induced pain. " 11/01/2007 - "Limonexic acid also produced dose-related inhibition of glutamate- and capsaicin-induced pain, with mean ID50 values of 11.67 (8.51-16.0) micromol kg(-1) and 47.17 (36.51-60.93) micromol kg(-1), respectively. "
4.	Breast Neoplasms (Breast Cancer) 02/01/2013 - "A panel of 9 purified limonoids, including limonin, nomilin, obacunone, limonexic acid (LNA), isolimonexic acid (ILNA), nomilinic acid glucoside (NAG), deacetyl nomilinic acid glucoside (DNAG), limonin glucoside (LG) and obacunone glucoside (OG) as well as 4 modified compounds such as limonin methoxime (LM), limonin oxime (LO), defuran limonin (DL), and defuran nomilin (DN), were screened for their cytotoxicity on estrogen receptor (ER)-positive (MCF-7) or ER-negative (MDA-MB-231) human breast cancer cells. "

Related Drugs and Biologics

1.	Limonins
2.	Acids
3.	nomilin
4.	limonin
5.	isoobacunoic acid
6.	Glutamic Acid (Glutamate)
7.	Estrogen Receptors
8.	Oximes
9.	Glucosides
10.	Formaldehyde (Formol)