RTA 502

05/22/2014 - "Collectively, our data show that HKH40A reduces BiP levels and this could have an important role in the activity of HKH40A against cancer cells. "
05/22/2014 - "We also demonstrate that HKH40A inhibited tumor formation in an in vivo xenograft tumor model. "
05/22/2014 - "HKH40A, the 8-methoxy analog of WMC79, is a synthetic agent with promising in vitro and in vivo antitumor activity, especially against solid tumors. "
05/22/2014 - "HKH40A downregulates GRP78/BiP expression in cancer cells."
05/22/2014 - "Here, we report that HKH40A markedly reduces the level of GRP78/BiP protein in cancer cell lines of various origin. "

04/01/2009 - "HKH40A (RTA 502), an optimized 8-methoxy analog of the unsymmetrical bifunctional antitumor agent WMC79, was found to be potently active against liver cancer cell growth in vitro and in vivo. "

10/01/2009 - "We found that HKH40A activated ataxia telangiectasia mutated (ATM) kinase, which then triggered activation of the Chk1/2 signaling pathway, evidenced by Chk1/2 mediated inhibitory phosphorylation of Cdc25C protein phosphatase. "