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epicoccamide D

glycosylated tetramic acid derivative from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa; structure in first source

Also Known As:

5-hydroxy-1,2-dimethyl-4-(2-methyl-18-beta-D-mannopyranosyloctadecanoyl)-1H-pyrrol-3(2H)one

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Mannosides: 99
    - epicoccamide D: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - epicoccamide D: 1

Experts

1.	Dahse, Hans-Martin: 1 article (11/2007)
2.	Hertweck, Christian: 1 article (11/2007)
3.	Wangun, Hilaire V Kemami: 1 article (11/2007)

Related Diseases

1.

11/01/2007 - "The derivative with the longest chain, epicoccamide D, induces morphogenesis and pigment formation in surface cultures of the fungus Phoma destructiva at a concentration of 1.7 mM. Moreover, it exhibits weak to moderate cytotoxicity to HeLa cell lines (CC50 17.0 microM) and antiproliferative effects toward mouse fibroplast (L-929) and human leukemia cell lines (K-562) with growth inhibition (GI50) of 50.5 and 33.3 microM, respectively."