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TAT-RasGAP(317-326)

a synthetic peptide that can sensitize tumor cells to genotoxins

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 445
        TAT-RasGAP(317-326): 4
- Peptides: 82426
  - Peptide Fragments: 373
    - TAT-RasGAP(317-326): 4
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 445
        TAT-RasGAP(317-326): 4

Experts

1.	Michod, David: 2 articles (07/2007 - 05/2007)
2.	Widmann, Christian: 2 articles (07/2007 - 05/2007)
3.	Barras, D: 1 article (10/2014)
4.	Lorusso, G: 1 article (10/2014)
5.	Rüegg, C: 1 article (10/2014)
6.	Widmann, C: 1 article (10/2014)
7.	Wei, Qichun: 1 article (12/2012)
8.	Xu, Jing: 1 article (12/2012)
9.	Cheng, Cai: 1 article (07/2007)
10.	Krueger, Thorsten: 1 article (07/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2012 - "TAT-RasGAP(317-326) is demonstrated to potentiate the efficacy of γ-irradiation-mediated cell killing both in tumor cell lines and in mouse tumor models, disregarding the status of p53, but not in non-cancer cells. " 10/30/2014 - "These results show that TAT-RasGAP(317-326), besides its ability to favor tumor cell death, hampers cell migration and invasion." 05/01/2007 - "These results indicate that TAT-RasGAP(317-326) sensitizes tumor cells by activating signals that intersect with the p53 pathway downstream of, or at the level of, proapoptotic p53 target gene products to increase the activation of the mitochondrial death pathway." 05/01/2007 - "The ability of TAT-RasGAP(317-326) to sensitize cancer cells was found to require PUMA but not p21. " 10/30/2014 - "In contrast, deleted in liver cancer-1, a tumor suppressor protein, the expression of which is often deregulated in cancer cells, was found to be required for TAT-RasGAP(317-326) to promote cell adherence and inhibit migration. "
2.	Malignant Mesothelioma 07/27/2007 - "Effect of the TAT-RasGAP(317-326) peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Cytostatic Agents
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
5.	Mutagens
6.	temoporfin
7.	1-phenyl-3,3-dimethyltriazene (PDT)

Related Therapies and Procedures

1.	Radiotherapy