larazotide acetate

an octapeptide inhibitor of paracellular permeability whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease; do not confuse with AT1001 deoxyjirimycin

Also Known As:

Networked: 20 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fasano, Alessio: 3 articles (02/2022 - 01/2021)
2.	Murray, Joseph A: 3 articles (01/2016 - 05/2012)
3.	Toll, Lawrence: 3 articles (10/2015 - 04/2015)
4.	Zaveri, Nurulain T: 3 articles (10/2015 - 04/2015)
5.	Blikslager, Anthony T: 2 articles (01/2021 - 01/2021)
6.	Krishnan, B Radha: 2 articles (01/2021 - 01/2021)
7.	Laumas, Sandeep: 2 articles (01/2021 - 01/2021)
8.	Messenger, Kristen M: 2 articles (01/2021 - 01/2021)
9.	Khroyan, Taline V: 2 articles (10/2015 - 04/2015)
10.	Yasuda, Dennis: 2 articles (10/2015 - 04/2015)

Related Diseases

1.	Fabry Disease (Fabry's Disease) 09/01/2020 - "ATTRACT (Study AT1001-012; NCT01218659) was a randomized, open-label, active-controlled study in patients aged 16-74 years with Fabry disease, an amenable GLA variant, and an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2. " 07/01/2015 - "Collectively, these data indicate that intravenous administration of ATB100 coformulated with AT1001 may provide an improved therapy for Fabry disease and thus warrants further investigation. "
2.	Arthritis (Polyarthritis) 01/01/2021 - "Treatment of mice with AT-1001, a molecule that prevents development of gut permeability, ameliorates arthritis. " 01/01/2020 - "Moreover, treatment with the zonulin antagonist larazotide acetate, which specifically increases intestinal barrier integrity, effectively reduces arthritis onset. "
3.	Celiac Disease (Celiac Sprue) 01/01/2022 - "Larazotide acetate for treatment of celiac disease: A systematic review and meta-analysis of randomized controlled trials." 01/01/2022 - "Tight junction regulation in celiac disease: role of larazotide acetate." 01/01/2021 - "In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model." 01/01/2016 - "The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate." 06/01/2015 - "Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial."
4.	Alcoholism (Alcohol Abuse) 06/01/2015 - "Here, to study the involvement of α3β4 nAChRs in the mechanisms that regulate alcohol abuse we evaluated the effects of AT-1001 on alcohol taking and seeking in Sprague-Dawley rats. "
5.	Cocaine-Related Disorders (Cocaine Addiction) 10/15/2015 - "Since the selective α3β4 nAChR functional antagonist AT-1001 has also been shown to block nicotine self-administration in rats, the present results suggest that α3β4 nAChRs may be a target for the treatment of cocaine addiction as well as for cocaine-nicotine comorbid addiction. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Glutens (Glutelin)
3.	zonulin
4.	larazotide acetate
5.	Nicotine
6.	Gliadin
7.	Cocaine (Cocaine HCl)
8.	Aminopropionitrile
9.	Varenicline (Chantix)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Gluten-Free Diet
3.	Self Administration (Administration, Self)