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dihydrochelerythrine

trypanocidal and antileishmanial dihydrochelerythrine derivative from Garcinia lucida; structure in first source

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzophenanthridines
    - dihydrochelerythrine: 7
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenanthridines: 3
      - Benzophenanthridines
        dihydrochelerythrine: 7
  - 4 or More Rings Heterocyclic Compounds
    - Benzophenanthridines
      - dihydrochelerythrine: 7

Experts

1.	Liu, Xin: 1 article (09/2022)
2.	Sun, Jianfang: 1 article (09/2022)
3.	Xu, Yijia: 1 article (09/2022)
4.	Yang, Liying: 1 article (09/2022)
5.	Zhang, Jinghai: 1 article (09/2022)
6.	Zhang, Suli: 1 article (09/2022)
7.	Zhao, Mingyi: 1 article (09/2022)
8.	Zhao, Shangfeng: 1 article (09/2022)
9.	Borges, Helena L: 1 article (01/2018)
10.	Clarêncio, Jorge: 1 article (01/2018)

Related Diseases

1.	Pain (Aches) 09/01/2022 - "In a patch clamp study, dihydrosanguinarine and dihydrochelerythrine, two monomers with the strongest binding effects, could inhibit the peak currents and promote both activation and inactivation phases of Nav1.5. Meanwhile, dihydrosanguinarine and dihydrochelerythrine could also inhibit peak currents and promote the activation phase of Nav1.7. Therefore, the findings from this study provide valuable information for future uses of traditional Chinese medicines to treat pain and cardiovascular disease."
2.	Cardiovascular Diseases (Cardiovascular Disease) 09/01/2022 - "In a patch clamp study, dihydrosanguinarine and dihydrochelerythrine, two monomers with the strongest binding effects, could inhibit the peak currents and promote both activation and inactivation phases of Nav1.5. Meanwhile, dihydrosanguinarine and dihydrochelerythrine could also inhibit peak currents and promote the activation phase of Nav1.7. Therefore, the findings from this study provide valuable information for future uses of traditional Chinese medicines to treat pain and cardiovascular disease."
3.	Prostatic Neoplasms (Prostate Cancer) 09/29/2017 - "A series of C(6)-substituted dihydrobenzo[c]phenanthridines were synthesized by mild copper-catalyzed C(sp3)-H functionalization of dihydrosanguinarine (2) and dihydrochelerythrine (3) with certain nucleophiles selected to enhance cytotoxicity against human breast, colorectal, and prostate cancer cell lines. "
4.	Neoplasms (Cancer) 12/08/2022 - "To tackle these challenges, we herein propose a photoactivation strategy with biogenic riboflavin as the photosensitizer to promote the in situ transformation of noncytotoxic dihydroalkaloid prodrugs dihydrochelerythrine (DHCHE), dihydrosanguinarine (DHSAN), and dihydronitidine (DHNIT) into anticancer alkaloid drugs chelerythrine (CHE), sanguinarine (SAN), and nitidine (NIT), respectively, which can efficiently kill cancer cells and inhibit in vivo tumor growth. "
5.	Necrosis 06/01/2008 - "We conclude that both chelerythrine and dihydrochelerythrine affect cell cycle distribution, activate mitochondrial apoptotic pathway, and induce apoptosis and necrosis in HL-60 cells." 06/01/2008 - "A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry. "

Related Drugs and Biologics

1.	dihydrosanguinarine
2.	Alkaloids
3.	chelerythrine
4.	Cytostatic Agents
5.	Catenins
6.	Photosensitizing Agents (Photosensitizers)
7.	Annexin A5
8.	Riboflavin (Vitamin B2)
9.	Propidium (Propidium Iodide)
10.	Prodrugs

Related Therapies and Procedures

1.	Therapeutics