HLA-C*08 antigen

Also Known As:

HLA Cw8; HLA-Cw*08 antigen, human; HLA-Cw*08, human; HLA-Cw8

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
      - Histocompatibility Antigens Class I: 1944
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6
      - Histocompatibility Antigens Class I: 1944
        HLA-C Antigens: 714
        HLA-C*08 antigen: 6

Experts

1.	Gatanaga, Hiroyuki: 2 articles (02/2008 - 01/2007)
2.	Oka, Shinichi: 2 articles (02/2008 - 01/2007)
3.	Gutiérrez Rodero, Félix: 1 article (05/2008)
4.	Sánchez Hellín, Victoria: 1 article (05/2008)
5.	Honda, Haruhito: 1 article (02/2008)
6.	Genka, Ikumi: 1 article (01/2007)
7.	Honda, Miwako: 1 article (01/2007)
8.	Kikuchi, Yoshimi: 1 article (01/2007)
9.	Tachikawa, Natsuo: 1 article (01/2007)
10.	Tanuma, Junko: 1 article (01/2007)

Related Diseases

1.	Hypersensitivity (Allergy) 01/11/2007 - "HLA-Cw8 primarily associated with hypersensitivity to nevirapine." 02/01/2008 - "Significant predisposition to nevirapine hypersensitivity has been reported in Caucasian Australians harboring HLA-DRB10101 with high CD4+ T-cell counts, and Sardinians and Japanese harboring HLA-Cw8. " 05/01/2008 - "The present review describes some of the adverse effects of antiretroviral drugs in which a genetic predisposition may be involved: efavirenz-induced neurological toxicity, generally associated with the 516G>T polymorphism of liver enzyme cytochrome P450 2B6 (CYP2B6); hypersensitivity reactions to nevirapine, associated with specific alleles of major histocompatibility complex, mainly the HLA-DRB10101 allele, which, in combination with a high CD4 lymphocyte count, has been associated with systemic reactions and hepatitis in Caucasians, and the HLA-Cw8 allele, which is associated with hypersensitivity reactions in persons from the Italian island of Sardinia and from Japan; nevirapine-induced hepatotoxicity associated with the C>T polymorphism in position 3435T of the ABCB1 (MDR-1) gene codifying for glycoprotein P (lower risk); hyperbilirubinemia in patients exposed to atazanavir or indinavir carrying the UGT1A1*28 polymorphism; peripheral neuropathy with nucleoside analogues associated with haplogroup T of the mitochondrial genome (higher risk) and with the HFE C282Y genotype of the hemochromatosis gene (lower risk); the mutation in codon 964 (R964C) of the POLG gene that codifies the mitochondrial polymerase DNA gamma described in a Thai patient with lactic acidosis; the ABCC2 gene haplotypes associated with tenofovir-induced proximal tubulopathy, and the risk of pancreatitis in persons with mutations in the CFTR and SPINK-1 genes."
2.	Genetic Predisposition to Disease (Genetic Predisposition) 05/01/2008 - "The present review describes some of the adverse effects of antiretroviral drugs in which a genetic predisposition may be involved: efavirenz-induced neurological toxicity, generally associated with the 516G>T polymorphism of liver enzyme cytochrome P450 2B6 (CYP2B6); hypersensitivity reactions to nevirapine, associated with specific alleles of major histocompatibility complex, mainly the HLA-DRB10101 allele, which, in combination with a high CD4 lymphocyte count, has been associated with systemic reactions and hepatitis in Caucasians, and the HLA-Cw8 allele, which is associated with hypersensitivity reactions in persons from the Italian island of Sardinia and from Japan; nevirapine-induced hepatotoxicity associated with the C>T polymorphism in position 3435T of the ABCB1 (MDR-1) gene codifying for glycoprotein P (lower risk); hyperbilirubinemia in patients exposed to atazanavir or indinavir carrying the UGT1A128 polymorphism; peripheral neuropathy with nucleoside analogues associated with haplogroup T of the mitochondrial genome (higher risk) and with the HFE C282Y genotype of the hemochromatosis gene (lower risk); the mutation in codon 964 (R964C) of the POLG gene that codifies the mitochondrial polymerase DNA gamma described in a Thai patient with lactic acidosis; the ABCC2 gene haplotypes associated with tenofovir-induced proximal tubulopathy, and the risk of pancreatitis in persons with mutations in the CFTR and SPINK-1 genes."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/1998 - "In type I psoriasis, special extended haplotypes such as EH57.1 (HLA-Cw6-B57-DRB10701-DQA10201-DQB10303) and EH65.1 (HLA-Cw8-B65-DRB10102-DQB1*0501) have been found to be increased. "
4.	Peripheral Nervous System Diseases (PNS Diseases) 05/01/2008 - "The present review describes some of the adverse effects of antiretroviral drugs in which a genetic predisposition may be involved: efavirenz-induced neurological toxicity, generally associated with the 516G>T polymorphism of liver enzyme cytochrome P450 2B6 (CYP2B6); hypersensitivity reactions to nevirapine, associated with specific alleles of major histocompatibility complex, mainly the HLA-DRB10101 allele, which, in combination with a high CD4 lymphocyte count, has been associated with systemic reactions and hepatitis in Caucasians, and the HLA-Cw8 allele, which is associated with hypersensitivity reactions in persons from the Italian island of Sardinia and from Japan; nevirapine-induced hepatotoxicity associated with the C>T polymorphism in position 3435T of the ABCB1 (MDR-1) gene codifying for glycoprotein P (lower risk); hyperbilirubinemia in patients exposed to atazanavir or indinavir carrying the UGT1A128 polymorphism; peripheral neuropathy with nucleoside analogues associated with haplogroup T of the mitochondrial genome (higher risk) and with the HFE C282Y genotype of the hemochromatosis gene (lower risk); the mutation in codon 964 (R964C) of the POLG gene that codifies the mitochondrial polymerase DNA gamma described in a Thai patient with lactic acidosis; the ABCC2 gene haplotypes associated with tenofovir-induced proximal tubulopathy, and the risk of pancreatitis in persons with mutations in the CFTR and SPINK-1 genes."
5.	Pancreatitis 05/01/2008 - "The present review describes some of the adverse effects of antiretroviral drugs in which a genetic predisposition may be involved: efavirenz-induced neurological toxicity, generally associated with the 516G>T polymorphism of liver enzyme cytochrome P450 2B6 (CYP2B6); hypersensitivity reactions to nevirapine, associated with specific alleles of major histocompatibility complex, mainly the HLA-DRB10101 allele, which, in combination with a high CD4 lymphocyte count, has been associated with systemic reactions and hepatitis in Caucasians, and the HLA-Cw8 allele, which is associated with hypersensitivity reactions in persons from the Italian island of Sardinia and from Japan; nevirapine-induced hepatotoxicity associated with the C>T polymorphism in position 3435T of the ABCB1 (MDR-1) gene codifying for glycoprotein P (lower risk); hyperbilirubinemia in patients exposed to atazanavir or indinavir carrying the UGT1A128 polymorphism; peripheral neuropathy with nucleoside analogues associated with haplogroup T of the mitochondrial genome (higher risk) and with the HFE C282Y genotype of the hemochromatosis gene (lower risk); the mutation in codon 964 (R964C) of the POLG gene that codifies the mitochondrial polymerase DNA gamma described in a Thai patient with lactic acidosis; the ABCC2 gene haplotypes associated with tenofovir-induced proximal tubulopathy, and the risk of pancreatitis in persons with mutations in the CFTR and SPINK-1 genes."

Related Drugs and Biologics

1.	Nevirapine (Viramune)
2.	HLA-DRB1 Chains (HLA DRB1)
3.	Cytochrome P-450 CYP2B6 (CYP2B6)
4.	Indinavir (Crixivan)
5.	Peptides (Polypeptides)
6.	Nucleosides
7.	Glycoproteins (Glycoprotein)
8.	Enzymes
9.	DNA-Directed DNA Polymerase (Polymerases, DNA)
10.	Codon (Codons)

Related Therapies and Procedures

1.	Autologous Transplantation