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PHA 680632

Aurora kinase inhibitor with potent antitumoral activity; structure in first source

Also Known As:

PHA-680632; PHA680632

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - PHA 680632: 2
    - Pyrazoles: 61
      - PHA 680632: 2

Experts

1.	Auperin, A: 1 article (12/2007)
2.	Bourhis, J: 1 article (12/2007)
3.	Deutsch, E: 1 article (12/2007)
4.	Frascogna, V: 1 article (12/2007)
5.	Lecluse, Y: 1 article (12/2007)
6.	Tao, Y: 1 article (12/2007)
7.	Zhang, P: 1 article (12/2007)
8.	Ballinari, Dario: 1 article (07/2006)
9.	Bravo, Rodrigo: 1 article (07/2006)
10.	Cappella, Paolo: 1 article (07/2006)

Related Diseases

1.

Neoplasms (Cancer)

12/17/2007 - "These results demonstrate that PHA680632 in association with radiation leads to an additive effect in cancer cells, especially in the p53-deficient cells, but does not act as a radiosensitiser in vitro or in vivo."
07/01/2006 - "PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses. "
12/17/2007 - "Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells."

Related Drugs and Biologics

1.	Aurora Kinases
2.	Aurora Kinase A
3.	Small Interfering RNA (siRNA)