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RC-1291

orally active ghrelin mimetic and growth hormone secretagogue

Also Known As:

ONO-7643

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Ghrelin: 5030
      - RC-1291: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Hormones: 1347
    - Ghrelin: 5030
      - RC-1291: 1

Experts

1.	Garcia, Jose M: 1 article (05/2007)
2.	Polvino, William J: 1 article (05/2007)

Related Diseases

1.	Body Weight (Weight, Body) 05/01/2007 - "This randomized, double-blind, placebo-controlled, multiple-dose, dose-escalation phase I study in healthy volunteers evaluated RC-1291 once daily (qd) and twice daily (bid) for effect on body weight and safety. " 05/01/2007 - "Results indicate that RC-1291 produces dose-related increases in body weight with no dose-limiting adverse effects, and may be an effective treatment for anorexia/cachexia." 05/01/2007 - "Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers."
2.	Cachexia 05/01/2007 - "Results indicate that RC-1291 produces dose-related increases in body weight with no dose-limiting adverse effects, and may be an effective treatment for anorexia/cachexia." 05/01/2007 - "RC-1291 is a novel, oral ghrelin mimetic and growth hormone (GH) secretagogue being developed to increase appetite and lean muscle mass in patients with cancer-associated anorexia/cachexia. "
3.	Anorexia 05/01/2007 - "Results indicate that RC-1291 produces dose-related increases in body weight with no dose-limiting adverse effects, and may be an effective treatment for anorexia/cachexia." 05/01/2007 - "RC-1291 is a novel, oral ghrelin mimetic and growth hormone (GH) secretagogue being developed to increase appetite and lean muscle mass in patients with cancer-associated anorexia/cachexia. "
4.	Weight Gain 05/01/2007 - "Subjects who received RC-1291, 50 or 75 mg, had significant dose-related weight gain after 6 days versus placebo, with the greatest increases seen with daily dosing. "
5.	Neoplasms (Cancer) 05/01/2007 - "RC-1291 is a novel, oral ghrelin mimetic and growth hormone (GH) secretagogue being developed to increase appetite and lean muscle mass in patients with cancer-associated anorexia/cachexia. "

Related Drugs and Biologics

1.	Ghrelin
2.	Growth Hormone (Somatotropin)
3.	Secretagogues