|1.||Ishida, Hiroyuki: 2 articles (12/2007 - 08/2007)|
|2.||Kuwabara, Takashi: 2 articles (12/2007 - 08/2007)|
|3.||Li, Pui-Kai: 2 articles (12/2007 - 08/2007)|
|4.||Sato, Natsuko: 2 articles (12/2007 - 08/2007)|
|5.||Nakata, Taisuke: 2 articles (12/2007 - 08/2007)|
|6.||Akinaga, Shiro: 2 articles (12/2007 - 08/2007)|
|7.||Shiotsu, Yukimasa: 1 article (12/2007)|
|8.||Terasaki, Yoko: 1 article (12/2007)|
|9.||Suzuki, Masayo: 1 article (12/2007)|
|10.||Tanaka, Hideyuki: 1 article (12/2007)|
08/01/2007 - "Expression of E1S-induced progesterone receptors in ZR-75-1 cells was reduced by treatment of KW-2581 at concentrations as low as 0.1 nM. Oral administration of KW-2581 for 4 weeks caused tumor shrinkage in a mouse xenograft model. "
12/01/2007 - "In a nitrosomethylurea-induced rat mammary tumor model, KW-2581 induced regression of E1S-stimulated tumor growth as effectively as tamoxifen or another STS inhibitor, 667 Coumate. "
|2.||Breast Neoplasms (Breast Cancer)
08/01/2007 - "These findings suggest that KW-2581 has considerable potential for therapeutic development as a novel anti-hormonal drug for treatment of breast cancer."
12/01/2007 - "These findings demonstrate that KW-2581 is a candidate for development as a therapeutic agent for the treatment of hormone receptors-positive breast cancer."
08/01/2007 - "Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo."
12/01/2007 - "A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models."
|1.||Steryl-Sulfatase (Steroid Sulfatase)
|3.||Progesterone Receptors (Progesterone Receptor)
|1.||Heterologous Transplantation (Xenotransplantation)