|1.||Wu, Yang-Chang: 11 articles (07/2013 - 09/2005)|
|2.||Chang, Fang-Rong: 7 articles (07/2013 - 09/2005)|
|3.||Ruan, Jinlan: 6 articles (10/2014 - 03/2011)|
|4.||Xiong, Chaomei: 5 articles (10/2014 - 03/2011)|
|5.||Xue, Pingping: 4 articles (10/2014 - 06/2012)|
|6.||Liu, Ziwei: 4 articles (05/2014 - 06/2012)|
|7.||Yuan, Qianying: 4 articles (02/2014 - 06/2012)|
|8.||Wu, Chin-Chung: 4 articles (07/2012 - 09/2005)|
|9.||Zhang, Xuenong: 3 articles (07/2013 - 06/2012)|
|10.||Yuan, Shyng-Shiou: 3 articles (07/2013 - 05/2011)|
07/05/2013 - "Recent studies highlighted that protoapigenone and some of its derivatives show very potent anticancer activity against several types of tumors, using both in vitro and in vivo models. "
07/01/2013 - "In this study, a total synthetic flavonoid protoapigenone, known as WYC02, was analysed for its potential anticancer activity on human cervical cancer cells as well as the underlying mechanisms for these effects. "
06/13/2013 - "In this study, we explored the anti-cancer activity of WYC02-9, a synthetic protoapigenone, on human HCT116 CRC cells. "
06/01/2012 - "To assess the anti-angiogenesis potential and mechanism of RY10-4, a derivative of protoapigenone, which was verified the broad-spectrum anti-tumor activities by previous study. "
08/18/2008 - "In nude mice study, protoapigenone treatment significantly suppressed the tumor growth, without major side effects. "
|2.||Breast Neoplasms (Breast Cancer)
07/15/2013 - "RY10-4, a modified version of protoapigenone, manifested better anti-proliferation activity in human breast cancer cell line MCF-7. "
07/15/2013 - "A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway."
11/28/2012 - "A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer."
12/01/2011 - "In this study, we investigated and compared the mechanisms by which protoapigenone and apigenin caused cell death in the human breast cancer MDA-MB-231 cells. "
05/01/2014 - "In the article, we investigated the anti-metastasis mechanism of RY10-4, an anti-tumor compound derived from protoapigenone, in breast tumor cells MB-MDA-231. "
|3.||Prostatic Neoplasms (Prostate Cancer)
06/01/2008 - "In this study, we investigated the anticancer effect of protoapigenone on human prostate cancer cells. "
05/01/2011 - "A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species."
06/01/2008 - "In conclusion, our results demonstrated protoapigenone suppressed prostate cancer cell growth through the activation of p38 MAPK and JNK1/2, with the potential to be developed as a chemotherapeutic agent for prostate cancer."
06/01/2008 - "Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2."
|4.||Ovarian Neoplasms (Ovarian Cancer)
08/18/2008 - "In the present study, we explored the cytotoxic effects of protoapigenone on ovarian cancer cells and the immortalized ovarian epithelial cells by XTT assay. "
08/18/2008 - "Taken together, protoapigenone showed a significant anti-ovarian cancer activity with low toxicity, suggesting its potential to be developed as a chemotherapeutic agent."
08/18/2008 - "Our results showed that protoapigenone had a significant cytotoxicity on human ovarian cancer cells MDAH-2774 and SKOV3 but not on the immortalized non-cancer ovarian epithelial cells HOSE 6-3 and HOSE 11-12. "
08/18/2008 - "Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo."
08/18/2008 - "The anti-ovarian cancer effect of protoapigenone was further examined using nude mice xenograft assay and immunohistochemistry. "
|5.||Hepatocellular Carcinoma (Hepatoma)
|2.||Protein Kinases (Protein Kinase)
|4.||p38 Mitogen-Activated Protein Kinases
|5.||Reactive Oxygen Species (Oxygen Radicals)
|9.||Glutathione Transferase (Glutathione S-Transferase)
|1.||Heterologous Transplantation (Xenotransplantation)