thiacremonone

results suggest that a sulfurocompound from garlic inhibited colon cancer cell growth through induction of apoptotic cell death by modulating of NF-kappaB; structure in first source

Networked: 12 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hong, Jin Tae: 11 articles (07/2016 - 08/2007)
2.	Ban, Jung Ok: 7 articles (07/2015 - 08/2007)
3.	Jeong, Heon Sang: 6 articles (07/2016 - 01/2012)
4.	Han, Sang Bae: 6 articles (05/2016 - 01/2009)
5.	Hwang, Bang Yeon: 5 articles (05/2016 - 08/2007)
6.	Jeong, Heon-Sang: 5 articles (05/2016 - 08/2007)
7.	Yoon, Do Young: 4 articles (07/2015 - 06/2009)
8.	Oh, Ki-Wan: 3 articles (07/2016 - 01/2012)
9.	Lee, Dong Hun: 3 articles (01/2014 - 09/2012)
10.	Choi, Dong-Young: 2 articles (07/2016 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2009 - "These results warrant carefully designed clinical studies investigating the combination of thiacremonone and commonly used chemotherapeutic agents for the treatment of human cancers." 06/01/2009 - "In the present study, we tested whether thiacremonone could increase susceptibility of cancer cells to chemotherapeutics through inactivation of NF-kappaB. " 01/01/2014 - "These data indicate that thiacremonone inhibits tumor growth via inhibition of glutathione peroxidase activity of PRDX6 through interaction. " 01/01/2014 - "Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6." 07/01/2015 - "In the present study, we investigated whether thiacremonone enhanced susceptibility of lung cancer cells to a common anti-cancer drug paclitaxel by further inhibition of NF-κB. "
2.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "These data suggest that thiacremonone may have potentially beneficial effects in lung cancer. " 07/01/2015 - "These data indicated that thiacremonone leads to increased apoptotic cell death in lung cancer cell lines through greater inhibition of NF-κB by the combination treatment with paclitaxel." 07/01/2015 - "We found that combination treatment with thiacremonone and paclitaxel was more susceptible (combination index; 0.40 in NCI-H460 cells and 0.46 in A549 cells) in cell growth inhibition of two types of lung cancer cell lines compared to a single agent treatment. " 07/01/2015 - "Enhanced cell growth inhibition by thiacremonone in paclitaxel-treated lung cancer cells." 01/01/2014 - "Thiacremonone further inhibited glutathione peroxidase activity in lung cancer cells. "
3.	Colonic Neoplasms (Colon Cancer) 06/01/2009 - "Colon cancer cells were cotreated with thiacremonone (50 microg/mL, half dose of IC(50)) and lower doses of each chemotherapeutic agent (half dose of IC(50)) for 24 hours. " 08/01/2007 - "Treatment with different concentrations (30 - 150 microg/ml) of thiacremonone for various periods (0 - 48 h) inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of apoptosis in a dose-dependent manner. " 08/01/2007 - "In this study, we investigated whether a sulfurcompound (named thiacremonone) isolated from garlic could modulate NF-kappaB activity and thereby induce apoptotic cell death of colon cancer cells. " 06/01/2009 - "Thiacremonone augments chemotherapeutic agent-induced growth inhibition in human colon cancer cells through inactivation of nuclear factor-{kappa}B." 06/01/2009 - "Previously, we reported that thiacremonone, a novel sulfur compound isolated from garlic, inhibited NF-kappaB and cancer cell growth with IC(50) values about 100 microg/mL in colon cancer cells. "
4.	Acute Liver Failure (Fulminant Hepatic Failure) 01/01/2013 - "This study was undertaken to examine the preventive effects of thiacremonone, a compound extracted from garlic, on APAP-induced acute hepatic failure in male C57BL/6J. " 01/01/2013 - "Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer Cells."
5.	Obesity 12/01/2012 - "Thiacremonone may be a promising compound for the treatment of obesity." 09/01/2012 - "Taken together, these results suggest that thiacremonone may play a vital role in improving the management of obesity and related metabolic syndromes via inhibition of lipid accumulation."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Paclitaxel (Taxol)
3.	Acetaminophen (Paracetamol)
4.	Drinking Water
5.	Sulfur Compounds (Compounds, Sulfur)
6.	Amyloid (Amyloid Fibrils)
7.	Cytostatic Agents
8.	Peroxiredoxin VI
9.	Presenilin-1
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Intraperitoneal Injections