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2- tert- butyl- 9- fluoro- 3,6- dihydro- 7H- benz(h)imidazo(4,5- f)isoquinoline- 7- one

a janus-activated kinase inhibitor

Also Known As:

pyridone 6

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridones: 14
      - 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one: 4

Experts

1.	Inoue, Hiromasa: 2 articles (11/2011 - 01/2011)
2.	Yoshida, Hideyuki: 2 articles (11/2011 - 01/2011)
3.	Yoshimura, Akihiko: 2 articles (11/2011 - 01/2011)
4.	Asakawa, Mayako: 1 article (11/2011)
5.	Inoue, Naoko: 1 article (11/2011)
6.	Morita, Rimpei: 1 article (11/2011)
7.	Nakagawa, Ryusuke: 1 article (11/2011)
8.	Nakao, Atsuhito: 1 article (11/2011)
9.	Tamiya, Taiga: 1 article (11/2011)
10.	Asai, Yukari: 1 article (01/2011)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2011 - "Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17."
2.	Skin Diseases (Skin Disease) 11/01/2011 - "In the current study, we found that pyridone 6 (P6), a pan-JAK inhibitor, delayed the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice. "
3.	Bone Resorption 01/01/2009 - "In this study, we investigated the effects of a pan-JAK inhibitor, pyridone 6, on osteoclast differentiation and bone-resorption in vitro and ex vivo. " 01/01/2009 - "Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression."
4.	Multiple Myeloma 10/01/2006 - "Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells."
5.	Asthma (Bronchial Asthma) 01/07/2011 - "Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma."

Related Drugs and Biologics

1.	Janus Kinase Inhibitors
2.	Phosphotransferases (Kinase)
3.	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)
4.	NF-kappa B (NF-kB)
5.	Ligands