alpha,beta-methyleneadenosine 5'-diphosphate

Also Known As:

AOPCP; APCP cpd; adenosine 5'-methylenediphosphate; adenosine-5 alpha, beta-methylene diphosphonate; adenosine-alpha,beta-methylene diphosphate; alpha,beta-methylene ADP; alpha,beta-methylene adenosine 5'-diphosphate; alpha,beta-methylene-adenosinediphosphate; alpha,beta-methyleneadenosine-5'-diphosphate

Networked: 32 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Colgan, Sean P: 2 articles (03/2008 - 10/2002)
2.	Agostinho, Paula: 1 article (01/2019)
3.	Andrade, Geanne M: 1 article (01/2019)
4.	Canas, Paula M: 1 article (01/2019)
5.	Carmo, Marta: 1 article (01/2019)
6.	Cunha, Rodrigo A: 1 article (01/2019)
7.	Duarte, Filipe V: 1 article (01/2019)
8.	Fernandes, Francisco D: 1 article (01/2019)
9.	Gonçalves, Francisco Q: 1 article (01/2019)
10.	Oses, Jean-Pierre: 1 article (01/2019)

Related Diseases

1.	Infarction (Infarctions) 03/01/1994 - "Furthermore, when AOPCP was infused during the ischemic preconditioning procedure (n = 6) or during 60 minutes of reperfusion (n = 6), the infarct size-limiting effect was partially blunted (infarct size, 21.3 +/- 2.5% and 19.5 +/- 2.4%, respectively). " 03/01/1994 - "AOPCP without ischemic preconditioning did not increase infarct size (n = 9). " 03/01/1994 - "AOPCP blunted the infarct size-limiting effect (infarct size, 38.8 +/- 4.9%). " 03/01/1994 - "To test whether the increase in 5'-nucleotidase activity decreases infarct size, we infused AOPCP 10 minutes before the ischemic preconditioning procedure and continued for 60 minutes after the onset of reperfusion (n = 8). " 05/01/1994 - "Intermittent alpha 1-adrenoceptor stimulation by methoxamine mimicked the increase in 5'-nucleotidase activity and the infarct size-limiting effect, which were abolished by alpha, beta,-methyleneadenosine 5'-diphosphate. "
2.	Hypoxia (Hypoxemia) 10/01/2002 - "In vivo studies in a murine hypoxia model revealed that hypoxia-induced CD73 may serve to protect the epithelial barrier, since the CD73 inhibitor alpha,beta-methylene ADP promotes increased intestinal permeability. " 01/01/2018 - "AOPCP also modified cardiovascular responses to hypoxia, as indicated by reduced elevations in heart rate and exaggerated changes in femoral vascular conductance and mean arterial blood pressure. " 08/01/1994 - "In addition, AOPCP decreased the basal work load and coronary flow of the heart, slightly attenuated the hypoxia-induced flow increase and prevented adenylate loss during hypoxia. " 03/01/1992 - "Coronary vascular resistance decreased during hypoxia but the decline in resistance was less in AOPCP treated hearts. " 01/01/2018 - "Inhibition of CD73 by α,β-methylene ADP (AOPCP) in the whole CB preparation in vitro reduced basal discharge frequency by 76 ± 5% and reduced sensory activity throughout graded hypoxia. "
3.	Body Weight (Weight, Body) 01/01/2018 - "The study shows that after 60 minutes of the 20 mg/kg intravenous injection of AOPCP (body weight dose), the concentration of AOPCP in blood diminished rapidly from 38.6 ± 5.0 µM (measured 5 minutes after the injection) to 6.4 ± 1.4 µM. "
4.	Ischemia 10/01/1998 - "min-1, respectively); here plasma AOPCP levels were established before and during PC but not during the subsequent prolonged ischemia. " 11/01/2005 - "During 220 min of ischemia, extracellular ATP levels significantly increased 1.3-fold in AOPCP-treated rats (12.62+/-0.65 nM, p < 0.01 versus normoxic level). " 06/01/1999 - "AOPCP significantly increased dialysate AMP levels; at 60 minutes ischemia AMP levels were 6.22 +/- 2.97 microM in control hearts and 38.60 +/- 5.69 microM in AOPCP treated hearts. " 07/01/1993 - "Inhibition of ecto-5'-nucleotidase by alpha,beta-methylene ADP and GMP did not affect basal adenosine outflow but potentiated "ischemia"-evoked adenosine outflow. " 06/01/1999 - "At 30 minutes ischemia dialysate adenosine concentrations were 19.47 +/- 2.72, 11.41 +/- 2.44, and 7.93 +/- 1.01 microM in control, homocysteine, and AOPCP hearts, respectively. "
5.	Colitis 03/15/2008 - "Likewise, enteral administration of the selective CD73 inhibitor alpha,beta-methylene ADP to cd73(+/+) mice resulted in a similar increase in severity of TNBS colitis. " 02/01/2009 - "alpha,beta-Methylene ADP (100 microM), an inhibitor of CD39, restored ATP-induced vasoconstriction in arterioles from mice with DSS-induced colitis. "

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	8-(4-sulfophenyl)theophylline
3.	Purinergic P1 Receptors (Adenosine Receptor)
4.	5'-Nucleotidase (5' Nucleotidase)
5.	Adenosine Triphosphate (ATP)
6.	alpha,beta-methyleneadenosine 5'-diphosphate
7.	Purinergic P1 Receptor Antagonists
8.	Adenosine Monophosphate (AMP)
9.	Adenosine Diphosphate (ADP)
10.	Trypan Blue

Related Therapies and Procedures

1.	Intravenous Injections