(Au(d2pypp)(2))Cl

d2pypp - 1,3-bis(di-2-pyridylphosphino)propane; induces apoptosis in breast cancer cells, has implications for anticancer therapeutics targeted to mitochondria; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Berners-Price, Susan J: 2 articles (11/2007 - 10/2007)
2.	Filipovska, Aleksandra: 2 articles (11/2007 - 10/2007)
3.	Humphreys, Anthony S: 1 article (11/2007)
4.	Koutsantonis, George A: 1 article (11/2007)
5.	Skelton, Brian W: 1 article (11/2007)
6.	White, Allan H: 1 article (11/2007)
7.	Leedman, Peter J: 1 article (10/2007)
8.	Nichols, Scott J: 1 article (10/2007)
9.	Rackham, Oliver: 1 article (10/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/21/2007 - "The in vitro cytotoxic activity of [Au(d2pypp)(2)]Cl was assessed in human normal and cancer breast cells and selective toxicity to the cancer cells found. " 10/01/2007 - "We show that this gold complex [Au(d2pypp)(2)]Cl, at submicromolar concentrations, selectively induces apoptosis in breast cancer cells but not in normal breast cells. " 10/01/2007 - "We show that [Au(d2pypp)(2)]Cl inhibits the activities of both thioredoxin and thioredoxin reductase and that this effect is more pronounced in the breast cancer cells. "
2.	Neoplasms (Cancer) 11/21/2007 - "The in vitro cytotoxic activity of [Au(d2pypp)(2)]Cl was assessed in human normal and cancer breast cells and selective toxicity to the cancer cells found. "

Related Drugs and Biologics

1.	Thioredoxin-Disulfide Reductase
2.	Thioredoxins
3.	Gold