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N- (2- (6- (4- ethylpiperazin- 1- yl)pyridin- 3- yl)propan- 2- yl)- 2- fluoro- 9- oxo- 9,10- dihydroacridine- 3- carboxamide

structure in first source

Also Known As:

BMS 566419; BMS-566419; BMS566419

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide: 1
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide: 1

Experts

1.	Eikyu, Yoshiteru: 1 article (11/2010)
2.	Kinugasa, Fumitaka: 1 article (11/2010)
3.	Kozuki, Yoshihiro: 1 article (11/2010)
4.	Kubo, Kaori: 1 article (11/2010)
5.	Morokata, Tatsuaki: 1 article (11/2010)
6.	Nakanishi, Tomonori: 1 article (11/2010)
7.	Noto, Takahisa: 1 article (11/2010)
8.	Seki, Nobuo: 1 article (11/2010)
9.	Umeno, Hitomi: 1 article (11/2010)

Related Diseases

1.	Ureteral Obstruction 11/01/2010 - "We evaluated the antifibrotic effects of BMS-566419, a chemically synthesized IMPDH inhibitor, using an experimental rat model, unilateral ureteral obstruction (UUO), in comparison with those of MMF. " 11/01/2010 - "Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats."
2.	Fibrosis (Cirrhosis) 11/01/2010 - "BMS-566419 by oral administration showed a significant and dose-dependent suppressive effect on UUO-induced renal fibrosis in histopathological experiments. " 11/01/2010 - "Expression levels of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-beta1 (TGF-β1), which play important roles in UUO-induced renal fibrosis, were also investigated to determine the mechanism by which BMS-566419 affects the progression of renal fibrosis. " 11/01/2010 - "Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats."

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
3.	Oxidoreductases (Dehydrogenase)
4.	Inosine

Related Therapies and Procedures

1.	Oral Administration