isosilybin A

has antineoplastic activity; structure in first source

Also Known As:

7-(4-bromobenzoyl)isosilybin A; isosilybin B; 4H-1-Benzopyran-4-one, 2-((2R,3R)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

Networked: 9 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonolignans: 40
        Silymarin: 1151
        isosilybin A: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonolignans: 40
        Silymarin: 1151
        isosilybin A: 9

Experts

1.	Oberlies, Nicholas H: 5 articles (10/2010 - 05/2005)
2.	Agarwal, Rajesh: 4 articles (10/2010 - 05/2005)
3.	Kroll, David J: 4 articles (10/2010 - 05/2005)
4.	Graf, Tyler N: 3 articles (04/2010 - 05/2005)
5.	Deep, Gagan: 2 articles (10/2010 - 07/2007)
6.	Nakanishi, Yuka: 2 articles (04/2010 - 05/2005)
7.	Wani, Mansukh C: 2 articles (04/2010 - 05/2005)
8.	Agarwal, R: 2 articles (06/2008 - 02/2006)
9.	Deep, G: 2 articles (06/2008 - 02/2006)
10.	Kroll, D J: 2 articles (06/2008 - 02/2006)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/15/2005 - "Whereas several other more abundant flavonolignans do ultimately influence the same end points at higher exposure concentrations, these findings are suggestive that extracts enriched for isosilybin B, or isosilybin B alone, might possess improved potency in prostate cancer prevention and treatment." 10/01/2010 - "Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling." 07/01/2007 - "Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells." 04/01/2010 - "The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints." 02/16/2006 - "Here, we assessed and compared the anticancer efficacy and associated mechanisms of silymarin and silibinin in human prostate cancer (PCA) PC3 cells; silymarin is comprised of silibinin and its other stereoisomers, including isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. "
2.	Carcinoma (Carcinomatosis) 06/26/2008 - "Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway." 07/01/2007 - "Here we have assessed the anticancer efficacy of two pure compounds isosilybin B and isosilybin A, isolated from silymarin, in human prostate carcinoma LNCaP and 22Rv1 cells. "
3.	Asthma (Bronchial Asthma) 11/01/2020 - "According to our study, isosilybin A and silydianin can control main symptoms of asthma by modulating immune responses." 11/01/2020 - "After isolating and purifying isosilybin A and silydianin, Balb/c mouse model of allergic asthma was produced using ovalbumin injection. " 11/01/2020 - "Isosilybin A and silydianin reduced eosinophilic infiltration of lungs, IL-4 and IL-5 levels in BAL fluid, IL-4 and IL-5 gene expressions, as well as AHR in Balb/c mouse model of asthma. " 11/01/2020 - "We herein aimed to compare the anti-inflammatory and anti-allergic effects of two silymarin isomers, isosilybin A and silydianin, in the treatment of allergic asthma. "
4.	Hepatocellular Carcinoma (Hepatoma) 03/30/2010 - "All compounds were well tolerated by Huh7 human hepatoma cells up to 80 muM, except for isosilybin B, which was toxic to cells above 10 muM. "
5.	Dehydration (Water Stress) 01/01/2016 - "Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. "

Related Drugs and Biologics

1.	isosilybin A
2.	Silymarin
3.	Flavonolignans
4.	silidianin
5.	Androgen Receptors (Androgen Receptor)
6.	Silybin (Lagosa)
7.	silychristin
8.	Anti-Allergic Agents (Antiallergic Agents)
9.	Interleukin-5 (Interleukin 5)
10.	Interleukin-4 (Interleukin 4)