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ON013100

structure in first source

Also Known As:

(E)-2,4,6-trimethoxystyryl-3- hydroxy-4-methoxybenzyl sulfone; ON 013100

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Styrenes: 6
        ON013100: 2
- Sulfur Compounds: 278
  - Sulfones: 534
    - ON013100: 2

Experts

1.	Reddy, E Premkumar: 2 articles (03/2013 - 09/2012)
2.	Reddy, M V Ramana: 2 articles (03/2013 - 09/2012)
3.	Cho, Sool Yeon: 1 article (03/2013)
4.	Cosenza, Stephen C: 1 article (03/2013)
5.	Pallela, Venkat: 1 article (03/2013)
6.	Panda, Gayatri: 1 article (03/2013)
7.	Roboz, John: 1 article (03/2013)
8.	Cosenza, Stephen: 1 article (09/2012)
9.	Gallo, James M: 1 article (09/2012)
10.	Guo, Ping: 1 article (09/2012)

Related Diseases

1.	Brain Neoplasms (Brain Tumor) 09/01/2012 - "ON013100 showed high brain and brain tumor penetration with Css(brain)/Css(plasma) and Css(brain tumor)/Css(plasma) ratios of 0.92 ± 0.26 and 1.35 ± 0.40, respectively; its prodrug ON013105 showed negligible brain and brain tumor penetration. " 09/01/2012 - "ON013105, not ON01910.Na, was identified as a potential anticancer drug candidate for further investigation in brain tumor chemotherapy based on the properties of ON013100." 09/01/2012 - "Using an orthotopic U87 glioma mouse model, brain and brain tumor distribution under steady-state conditions were evaluated for ON01910.Na and ON013105/ON013100; anticancer potential following a multiple-dose schedule of 250 mg/kg/day IP for 7 days was evaluated for ON01910.Na. " 09/01/2012 - "To evaluate a mitotic inhibitor, ON01910.Na, as a potential chemotherapeutic agent for brain tumors using a series of PK/PD studies, which led to the evaluation of its structural analog, ON013105, a prodrug of the more lipophilic product, ON013100. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/05/2013 - "ON 013100, (E)-2,4,6-trimethoxystyryl-3-hydroxy-4-methoxybenzyl sulfone, is a potent kinase inhibitor whose phosphate form is in Phase I clinical trials in lymphoma and acute lymphoid leukemia. "
3.	Lymphoma (Lymphomas) 03/05/2013 - "ON 013100, (E)-2,4,6-trimethoxystyryl-3-hydroxy-4-methoxybenzyl sulfone, is a potent kinase inhibitor whose phosphate form is in Phase I clinical trials in lymphoma and acute lymphoid leukemia. "
4.	Glioma (Gliomas) 09/01/2012 - "Using an orthotopic U87 glioma mouse model, brain and brain tumor distribution under steady-state conditions were evaluated for ON01910.Na and ON013105/ON013100; anticancer potential following a multiple-dose schedule of 250 mg/kg/day IP for 7 days was evaluated for ON01910.Na. "
5.	Colonic Neoplasms (Colon Cancer) 03/05/2013 - "The objectives were to: (a) investigate the possible presence of the glucuronide metabolite of the drug in two representative colon cancer cell lines, a drug resistant (colo-205) and a drug sensitive (colo-320); (b) quantify the glucuronide metabolite and the unchanged drug in the cells after treatment with ON 013100. " 03/05/2013 - "Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS."

Related Drugs and Biologics

1.	Prodrugs
2.	ON 01910
3.	Glucuronides
4.	Sulfones
5.	Phosphotransferases (Kinase)
6.	Phosphates (Orthophosphate)
7.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)