ELN441958

bradykinin B1 Receptor antagonist; structure in first source

Also Known As:

7-chloro-2-(3-(9-pyridin-4-yl-3,9-diazaspiro(5.5)undecanecarbonyl)phenyl)-2,3-dihydro-isoindol-1-one

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Pain (Aches) 08/01/2007 - "Because ELN441958 is up to 120-fold more potent at primate than at rodent B(1) receptors, it was evaluated in a primate pain model. " 08/01/2007 - "ELN441958 is a novel small molecule bradykinin B(1) receptor antagonist exhibiting high oral bioavailability and potent systemic efficacy in rhesus monkey inflammatory pain."
2.	Hyperalgesia 08/01/2007 - "ELN441958 dose-dependently reduced carrageenan-induced thermal hyperalgesia in a rhesus monkey tail-withdrawal model, with an ED(50) approximately 3 mg/kg s.c. "