|1.||Zawel, Leigh: 3 articles (08/2011 - 02/2007)|
|2.||Keating, Joanna: 2 articles (12/2012 - 08/2011)|
|3.||Ziegler, David S: 2 articles (12/2012 - 08/2011)|
|4.||Kung, Andrew L: 2 articles (08/2011 - 07/2007)|
|5.||Tran, Mary: 2 articles (07/2007 - 02/2007)|
|6.||Mitsiades, Constantine: 2 articles (07/2007 - 02/2007)|
|7.||Haber, Michelle: 1 article (12/2012)|
|8.||Ingram, Wendy J: 1 article (12/2012)|
|9.||Hallahan, Andrew R: 1 article (12/2012)|
|10.||Tsoli, Maria: 1 article (12/2012)|
02/01/2007 - "In human MM xenograft mouse models, LBW242 is well tolerated, inhibits tumor growth, and prolongs survival. "
08/01/2011 - "Neurosphere assays revealed that the combination of radiation and LBW242 led to a pro-apoptotic effect in these glioma-initiating cell-enriched assays, with a corresponding inhibition of primary tumor cell growth. "
07/01/2007 - "administration of vehicle, LBW242 (50 mg/kg/day), PKC412 (40 mg/kg/day), or a combination of LBW242 and PKC412; the lowest tumor burden was observed in the drug combination group. "
08/01/2011 - "Athymic mice bearing established human malignant glioma tumor xenografts treated with LBW242 plus radiation and temozolomide demonstrated a synergistic suppression of tumor growth. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2012 - "LBW242 sensitizes ovarian cancer cells to the antitumor effects of TRAIL and anticancer drugs commonly used in clinic. "
01/01/2012 - "The effects of LBW242 on ovarian cancer cell lines and primary ovarian cancer cells was determined by cell proliferation, apoptosis and biochemical assays. "
01/01/2012 - "These observations suggest that the SMAC/DIABLO mimic LBW242 could be of value for the development of experimental strategies for treatment of ovarian cancer."
01/01/2012 - "LBW242 added alone elicited only a moderate pro-apoptotic effect; however, it strongly synergizes with tumor necrosis factor-related apoptosis inducing ligand (TRAIL) or anticancer drugs in inducing apoptosis of both ovarian cancer cell lines and primary ovarian cancer cells. "
01/01/2012 - "We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on ovarian cancer cell lines (A2780 cells and its chemoresistant derivative A2780/ADR, SKOV3 and HEY cells) and in primary ovarian cancer cells. "
05/15/2012 - "Human and murine neuroblastoma cells were treated with the Smac mimetic LBW242 alone or in combination with cytotoxic drugs used clinically to treat neuroblastoma. "
05/15/2012 - "Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis."
05/15/2012 - "Treatment with LBW242 sensitized human and murine neuroblastoma cells to chemotherapy-induced apoptosis, which was mediated by activation of both the intrinsic and extrinsic apoptosis pathways. "
|5.||Melanoma (Melanoma, Malignant)
|1.||Inhibitor of Apoptosis Proteins
|2.||Caspase 8 (Caspase-8)
|3.||Small Interfering RNA (siRNA)
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)