ior c5 monoclonal antibody

an IgG1 antibody which recognizes glycoprotein tumor specific antigen IOR C2 over expressed in the surface of colon and ovarian cancer cells; immunoscintigraphy with 99mTc-labeled mAb ior c5 could be a useful procedure for the diagnosis and follow-up of the patients with colorectal tumors, its metastasis and recurrences

Also Known As:

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Iznaga-Escobar, N: 2 articles (11/2004 - 06/2004)
2.	Aroche, Leonel T: 1 article (01/2007)
3.	Cordero, Maria: 1 article (01/2007)
4.	Crombet, Ramos T: 1 article (01/2007)
5.	González, Joaquín: 1 article (01/2007)
6.	Iznaga-Escobar, Normando: 1 article (01/2007)
7.	Mesa, Nelson Rodríguez: 1 article (01/2007)
8.	Oliva, Juan P: 1 article (01/2007)
9.	Pimentel, Gilmara: 1 article (01/2007)
10.	Pintado, Alejandro P: 1 article (01/2007)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2004 - "This study was designed to investigate the pharmacokinetics, biodistribution and the absorbed radiation doses of (99m)Tc-labeled mAb ior C5 antibody in colorectal tumor patients. " 11/01/2004 - "The very good pattern of biodistribution of (99m)Tc-labeled mAb ior C5 in patients will allow imaging of colorectal carcinoma lesions." 01/01/2007 - "The aim of the present work was to evaluate the diagnostic efficacy of the 99mTc-labeled mAb ior c5 for the detection of colorectal tumors, its metastases and recurrences. " 01/01/2007 - "Immunoscintigraphy with 99mTc-labeled mAb ior c5 could be a useful procedure for the diagnosis and follow-up of the patients with colorectal tumors, its metastasis and recurrences." 11/01/2004 - "(99m)Tc-labeled murine ior C5 monoclonal antibody in colorectal carcinoma patients: pharmacokinetics, biodistribution, absorbed radiation doses to normal organs and tissues and tumor localization."
2.	Neoplasm Metastasis (Metastasis) 01/01/2007 - "The aim of the present work was to evaluate the diagnostic efficacy of the 99mTc-labeled mAb ior c5 for the detection of colorectal tumors, its metastases and recurrences. " 01/01/2007 - "Immunoscintigraphy with 99mTc-labeled mAb ior c5 could be a useful procedure for the diagnosis and follow-up of the patients with colorectal tumors, its metastasis and recurrences."
3.	Neoplasms (Cancer) 01/01/2007 - "Eighty six patients with colorectal or anal cancer, mean age 57 +/- 13 yrs, were involved in a phase 1/11 multicentric, open clinical trial to assess the ability of Radioimmunoscintigraphy (RIS) with 99mTc- mAb ior c5 to detect those tumors. " 11/01/2004 - "(99m)Tc-labeled murine ior C5 monoclonal antibody in colorectal carcinoma patients: pharmacokinetics, biodistribution, absorbed radiation doses to normal organs and tissues and tumor localization." 06/01/2004 - "The results herein support the feasibility of directing StI to the surface of cancer cells expressing ior C2 Ag via the mAb ior C5." 01/01/2007 - "Monoclonal antibody (mAb) ior c5 is an IgG1, which recognizes a glycoprotein tumor specific antigen IOR C2 over expressed in the surface of colon and ovarian cancer cells. " 11/01/2004 - "Monoclonal Antibody (mAb) ior C5 is a murine IgG(1) that recognizes the tumor associated antigen (TAA) ior C2, a cell surface O-linked glycoprotein carbohydrate chain not present in most normal tissues and homogeneously expressed in the cytoplasm of normal colon epithelium and heterogeneously expressed in more than 83% of primary colorectal carcinomas. "
4.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 06/01/2004 - "The results herein support the feasibility of directing StI to the surface of cancer cells expressing ior C2 Ag via the mAb ior C5." 06/01/2004 - "Sticholysin I (StI), a potent cytolysin isolated from the sea anemone Stichodactyla helianthus, was linked to the monoclonal antibody (mAb) ior C5. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2007 - "Monoclonal antibody (mAb) ior c5 is an IgG1, which recognizes a glycoprotein tumor specific antigen IOR C2 over expressed in the surface of colon and ovarian cancer cells. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Immunoglobulin G (IgG)
3.	Glycoproteins (Glycoprotein)
4.	Antigens
5.	Perforin
6.	Carbohydrates
7.	stycholysin I