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chlorojanerin

from Centaurea solstitialis L.; structure in first source

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - chlorojanerin: 4
- Lactones: 1549
  - chlorojanerin: 4

Experts

1.	Hajdú, Zsuzsanna: 1 article (08/2019)
2.	Hohmann, Judit: 1 article (08/2019)
3.	Kivcak, Bijen: 1 article (08/2019)
4.	Kúsz, Norbert: 1 article (08/2019)
5.	Sinka, Izabella: 1 article (08/2019)
6.	Tastan, Pelin: 1 article (08/2019)
7.	Zupkó, István: 1 article (08/2019)
8.	Chakrabarty, Debarshi: 1 article (08/2012)
9.	Dagia, Nilesh M: 1 article (08/2012)
10.	Hegde, Bindu: 1 article (08/2012)

Related Diseases

1.	Neoplasms (Cancer) 03/29/2023 - "The goal of this study was to assess the anticancer efficacy of chlorojanerin against various cancer cells. "
2.	Ulcer 06/13/2007 - "Chlorojanerin was shown to be significantly effective in preventing the induction of lesions by ethanol- (EtOH-) (both oral and subcutaneous administration), indomethacin-, indomethacin plus HCl/EtOH-, N(G)-nitro-l-arginine methyl ester plus EtOH-, N-ethylmaleimide plus EtOH-, water immersion and restraint stress, and serotonin, as well as inhibiting titratable gastric acidity and acid output, and increasing gastric pH, but was ineffective in the prevention of ulcers induced by pyloric ligation, diethyldithiocarbamate, and cysteamine, and had no effect on gastric secretion volume or peptic activity. "
3.	Triple Negative Breast Neoplasms 08/30/2019 - "The highest activities were demonstrated by the chlorine-containing derivatives chlorojanerin (1) and 19-deoxychlorojanerin (2) with IC50 values of 2.21 and 2.88 µM, respectively, against the triple negative breast cancer model MDA-MB-231 cells."
4.	Lung Neoplasms (Lung Cancer) 03/29/2023 - "Collectively, our results demonstrate that chlorojanerin mediated an anticancer effect involving cell cycle arrest and apoptotic cell death and, therefore, could potentially serve as a therapeutic agent in lung cancer treatment." 03/29/2023 - "According to MTT assay, chlorojanerin inhibited the proliferation of all tested cells in a dose-dependent manner with a promising effect against A549 lung cancer cells with an IC50 of 10 µM. " 03/29/2023 - "Assessment of the Anticancer Effect of Chlorojanerin Isolated from Centaurothamnus maximus on A549 Lung Cancer Cells."
5.	Leukemia 08/15/2012 - "The extract blocked TNF-α and IL-6 production in LPS stimulated THP-1 cells (human acute monocyte leukemia cell line) completely at 10 and 30 μg/ml. The plant has been found as a new source of chlorojanerin, a guaianolide type of sesquiterpene lactone. "

Related Drugs and Biologics

1.	NG-Nitroarginine Methyl Ester (L-NAME)
2.	Serotonin (5 Hydroxytryptamine)
3.	Indomethacin (Indometacin)
4.	Ethylmaleimide (N-Ethylmaleimide)
5.	Ditiocarb (Sodium Diethyldithiocarbamate)
6.	Cysteamine (Mercaptamine)
7.	Ethanol (Ethyl Alcohol)
8.	Acids
9.	Interleukin-6 (Interleukin 6)
10.	Sesquiterpenes

Related Therapies and Procedures

1.	Ligation