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isoobtusilactone A

structure in first source

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - isoobtusilactone A: 5
- Lactones: 1549
  - isoobtusilactone A: 5

Experts

1.	Chen, Chung-Yi: 4 articles (04/2012 - 07/2007)
2.	Chern, Chi-Liang: 2 articles (04/2012 - 07/2007)
3.	Yiin, Shuenn-Jiun: 2 articles (04/2012 - 07/2007)
4.	Chen, Ching-Hsein: 2 articles (06/2008 - 07/2007)
5.	Borges, Beatriz Santana: 1 article (01/2021)
6.	Ceole, Lígia Fernanda: 1 article (01/2021)
7.	Ferreira, Alda Maria Teixeira: 1 article (01/2021)
8.	Garcez, Fernanda Rodrigues: 1 article (01/2021)
9.	Garcez, Walmir Silva: 1 article (01/2021)
10.	Klimeck, Tabata D'Maiella Freitas: 1 article (01/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/01/2007 - "In this study, the effects of isoobtusilactone A, a novel constituent isolated from the leaves of Cinnamomum kotoense, on the proliferation of human hepatoma Hep G2 cells were studied. " 04/04/2012 - "Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5." 04/04/2012 - "We have previously shown that isoobtusilactone A (IOA), a potent anticancer agent isolated from Cinnamomum kotoense, induced mitochondria-mediated apoptosis in hepatoma cells. " 07/01/2007 - "Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/01/2008 - "In this study, we investigate the anticancer effect of isoobtusilactone A (IOA), a constituent isolated from the leaves of Cinnamomum kotoense, on human non-small cell lung cancer (NSCLC) A549 cells. "
3.	Breast Neoplasms (Breast Cancer) 08/01/2007 - "This study is the first to investigate the anticancer effect of isoobtusilactone A (IOA) in two human breast cancer cell lines, MCF-7 and MDA-MB-231. " 08/01/2007 - "Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells."
4.	Chagas Disease (American Trypanosomiasis) 01/01/2021 - "Altogether, our results highlight the potential of butanolides against the etiologic agent of Chagas disease and the relevance of isoobtusilactone A as a strong anti-T. "
5.	Infections 01/01/2021 - "The most active compound, isoobtusilactone A, which showed activity against all tested strains inhibited metacyclogenesis and infection of new host cells. "

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