1- (4- (benzothiazol- 2- yloxy)benzyl)piperidine- 4- carboxylic acid

an NSAID with leukotriene A4 hydrolase inhibitory activity; structure in first source

Also Known As:

JNJ 26993135; JNJ-26993135; JNJ26993135

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid: 2
  - Piperidines: 17
    - 1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - 1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid: 2

Experts

1.	Berko, A: 1 article (03/2008)
2.	Dunford, P J: 1 article (03/2008)
3.	Fourie, A M: 1 article (03/2008)
4.	Horvath, K: 1 article (03/2008)
5.	Lundeen, K A: 1 article (03/2008)
6.	Posa, A: 1 article (03/2008)
7.	Riley, J P: 1 article (03/2008)
8.	Varga, C: 1 article (03/2008)
9.	Whittle, B J R: 1 article (03/2008)
10.	Coles, Fawn: 1 article (06/2007)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 03/01/2008 - "These results with JNJ 26993135 in the rat TNBS model support the role of LTB(4) in colitis and the potential value of targeting LTA(4)H for the treatment of inflammatory bowel diseases."
2.	Peritonitis 06/01/2007 - "In murine whole blood and in zymosan-induced peritonitis, JNJ-26993135 selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production, while maintaining or increasing production of the anti-inflammatory mediator, lipoxin (LX) A(4). "
3.	Otitis 06/01/2007 - "In a murine model of arachidonic acid-induced ear inflammation, the LTA(4)H inhibitor, JNJ-26993135 (1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid), dose-dependently inhibited ex vivo LTB(4) production in blood, in parallel with dose-dependent inhibition of neutrophil influx (ED(50), 1-3 mg/kg) and ear edema. "
4.	Edema (Dropsy) 06/01/2007 - "In a murine model of arachidonic acid-induced ear inflammation, the LTA(4)H inhibitor, JNJ-26993135 (1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid), dose-dependently inhibited ex vivo LTB(4) production in blood, in parallel with dose-dependent inhibition of neutrophil influx (ED(50), 1-3 mg/kg) and ear edema. "
5.	Colitis 03/01/2008 - "These results with JNJ 26993135 in the rat TNBS model support the role of LTB(4) in colitis and the potential value of targeting LTA(4)H for the treatment of inflammatory bowel diseases." 03/01/2008 - "The effect of oral administration of JNJ 26993135 has been evaluated in a rat model of colitis provoked by colonic instillation of trinitrobenzenesulphonic acid (TNBS). "

Related Drugs and Biologics

1.	Lipoxins
2.	Arachidonic Acid (Vitamin F)
3.	Zymosan
4.	Carboxylic Acids
5.	Acids
6.	cysteinyl-leukotriene
7.	piperidine

Related Therapies and Procedures

1.	Oral Administration