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ethyl 4- (4- ((2- hydroxy- 3- (4- hydroxy- 3- ((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoate

Also Known As:

SAR 150640; SAR-150640; SAR150640

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bardou, M: 1 article (03/2010)
2.	Dumas, M: 1 article (03/2010)
3.	Goirand, F: 1 article (03/2010)
4.	Lirussi, F: 1 article (03/2010)
5.	Morrison, J J: 1 article (03/2010)
6.	O'Brien, M: 1 article (03/2010)
7.	Sagot, P: 1 article (03/2010)
8.	Wendremaire, M: 1 article (03/2010)
9.	Advenier, Charles: 1 article (06/2007)
10.	Bardou, Marc: 1 article (06/2007)

Related Diseases

1.	Neuroblastoma 06/01/2007 - "SAR150640 and its major metabolite, the corresponding acid 4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl) amino] phenoxy]propyl)amino]cyclohexyl]benzoic acid (SSR500400), showed high affinity for beta(3)-adrenoceptors (K(i) = 73 and 358 nM) and greater potency than (-)-isoproterenol in increasing cAMP production in membrane preparations from human neuroblastoma cells (SKNMC), which express native beta(3)-adrenoceptors (pEC(50) = 6.5, 6.2, and 5.1, respectively). "
2.	Premature Obstetric Labor (Premature Labor) 06/01/2007 - "These findings indicate a potential for the therapeutic use of SAR150640 in mammals during preterm labor." 06/01/2007 - "Ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino] phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640) was characterized as a new potent and selective beta(3)-adrenoceptor agonist for the treatment of preterm labor. " 06/01/2007 - "In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor."
3.	Chorioamnionitis 03/01/2010 - "SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Matrix Metalloproteinases (MMPs)
3.	Benzoic Acid (Potassium Benzoate)
4.	Isoproterenol (Isoprenaline)
5.	Benzoates (Benzoate)
6.	Acids