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2- ((R)- 2- methylpyrrolidin- 2- yl)- 1H- benzimidazole- 4- carboxamide

an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models; structure in first source
Also Known As:
ABT-888
Networked: 50 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Giranda, Vincent L: 9 articles (02/2010 - 05/2007)
2. Liu, Xuesong: 6 articles (12/2009 - 05/2007)
3. Shi, Yan: 6 articles (12/2009 - 05/2007)
4. Rubinstein, Larry: 5 articles (09/2011 - 11/2008)
5. Doroshow, James H: 5 articles (09/2011 - 11/2008)
6. Tomaszewski, Joseph E: 5 articles (09/2011 - 11/2008)
7. Rodriguez, Luis E: 5 articles (12/2009 - 05/2007)
8. Zhu, Gui-Dong: 5 articles (12/2009 - 05/2007)
9. Luo, Yan: 5 articles (10/2009 - 05/2007)
10. Nowsheen, Somaira: 4 articles (08/2014 - 01/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Glioblastoma (Glioblastoma Multiforme)
3. Colonic Neoplasms (Colon Cancer)
4. Gastrointestinal Neoplasms (Gastrointestinal Cancer)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2. temozolomide (Temodar)
3. irinotecan (Camptosar)
4. oxaliplatin (Eloxatin)
5. Curcumin
6. gemcitabine
7. Cyclooxygenase 2 (Cyclooxygenase-2)
8. Focal Adhesion Protein-Tyrosine Kinases
9. Doxorubicin (Adriamycin)
10. Carbon Monoxide

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Homologous Transplantation (Allograft)
5. Anesthesia