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triptycene

structure in first source
Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Hua, Duy H: 7 articles (07/2006 - 05/2002)
2. Perchellet, Elisabeth M: 7 articles (07/2006 - 05/2002)
3. Wang, Yang: 6 articles (07/2006 - 07/2002)
4. Perchellet, Jean-Pierre H: 4 articles (07/2006 - 08/2003)
5. Tamura, Masafumi: 4 articles (08/2003 - 05/2002)
6. Lou, Kaiyan: 3 articles (07/2006 - 11/2004)
7. Zhao, Huiping: 2 articles (07/2006 - 01/2006)
8. Battina, Srinivas K: 2 articles (07/2006 - 01/2006)
9. Perchellet, Jean-Pierre: 2 articles (07/2002 - 05/2002)
10. Sperfslage, Bonnie J: 2 articles (07/2002 - 05/2002)

Related Diseases

1. Neoplasms (Cancer)
07/01/2006 - "Novel substituted triptycene bisquinones and 1, 4-anthracenediones were synthesized and screened for their anti-cancer activities. "
07/01/2002 - "In contrast to their inactive parent compound triptycene (code name TT0), several new synthetic analogs (TT code number) have antileukemic activities and remain effective in daunorubicin (DAU)-resistant tumor sublines in vitro. "
01/01/2006 - "Since synthetic analogs of triptycene (TT code number), such as bisquinones TT2 and TT13, can trigger cytochrome c release without caspase activation and retain their ability to induce apoptosis in multidrug-resistant (MDR) tumor cells, fluorescent probes of transmembrane potential have been used to determine whether these antitumor compounds might directly target mitochondria in cell and cell-free systems to cause the collapse of mitochondrial membrane potential ( downward arrow Deltapsim) that is linked to permeability transition pore (PTP) opening. "
08/01/2003 - "Synthetic triptycene analogs (TT code number) mimic the antitumor effects of daunorubicin in the nanomolar range in vitro, but have the advantage of blocking nucleoside transport and retaining their efficacy in multidrug-resistant (MDR) tumor cells. "
11/01/2004 - "Synthetic triptycene analogs (TT code number) mimic the antitumor effects of daunorubicin (DAU) in vitro, but have the advantage of blocking nucleoside transport, inhibiting both DNA topoisomerase I and II activities, and retaining their efficacy in multidrug-resistant (MDR) tumor cells. "
2. Leukemia L1210
3. Hepatocellular Carcinoma (Hepatoma)
4. Dehydration (Water Stress)

Related Drugs and Biologics

1. Daunorubicin (Cerubidine)
2. tebufenozide (Mimic)
3. Cytochromes c (Cytochrome c)
4. Fluorescent Dyes (Fluorescent Probes)
5. Type I DNA Topoisomerases (Topoisomerase I)
6. acetaldehyde oxime (acetaldoxime)
7. benzoquinone (quinone)