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VRX0466617

selective inhibitor of checkpoint kinase Chk2; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - VRX0466617: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - VRX0466617: 1

Experts

1.	Buscemi, Giacomo: 1 article (03/2007)
2.	Carlessi, Luigi: 1 article (03/2007)
3.	Delia, Domenico: 1 article (03/2007)
4.	Hong, Zhi: 1 article (03/2007)
5.	Larson, Gary: 1 article (03/2007)
6.	Wu, Jim Zhen: 1 article (03/2007)

Related Diseases

1.	Ataxia Telangiectasia (Louis Bar Syndrome) 03/01/2007 - "These doses of VRX0466617 inhibited, to some extent, the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), which is phosphorylated by the upstream ataxia-telangiectasia mutated (ATM) kinase. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)