HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

(S)- (1- azabicyclo(2.2.2)oct- 3- yl)carbamic acid (S)-1-(2-fluorophenyl) ethyl ester

a nicotinic receptor alpha7 selective agonist; structure in first source

Also Known As:

JN403

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - (S)-(1-azabicyclo(2.2.2)oct-3-yl)carbamic acid (S)-1-(2-fluorophenyl) ethyl ester: 2
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Quinuclidines: 20
    - (S)-(1-azabicyclo(2.2.2)oct-3-yl)carbamic acid (S)-1-(2-fluorophenyl) ethyl ester: 2

Experts

1.	Feuerbach, Dominik: 2 articles (05/2010 - 01/2009)
2.	Arias, Hugo R: 1 article (05/2010)
3.	Gu, Ruo-Xu: 1 article (05/2010)
4.	Wei, Dong-Qing: 1 article (05/2010)
5.	Bilbe, Graeme: 1 article (01/2009)
6.	Chaperon, Frederique: 1 article (01/2009)
7.	Enz, Albert: 1 article (01/2009)
8.	Gentsch, Conrad: 1 article (01/2009)
9.	Hoyer, Daniel: 1 article (01/2009)
10.	Lingenhoehl, Kurt: 1 article (01/2009)

Related Diseases

1.	Pain (Aches) 01/01/2009 - "Altogether, the present set of data suggests that nAChR alpha7 agonists, like JN403 may be beneficial for improving learning/memory performance, restoring sensory gating deficits, and alleviating pain, epileptic seizures and conditions of anxiety." 05/18/2010 - "The higher receptor specificity for JN403 could be important for the treatment of alpha7-related disorders, including dementias, pain-related ailments, depression, anxiety, and wound healing." 01/01/2009 - "In the two models of permanent pain tested, JN403 produces a significant reversal of mechanical hyperalgesia. " 01/01/2009 - "The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain."
2.	Seizures (Absence Seizure) 01/01/2009 - "Altogether, the present set of data suggests that nAChR alpha7 agonists, like JN403 may be beneficial for improving learning/memory performance, restoring sensory gating deficits, and alleviating pain, epileptic seizures and conditions of anxiety."
3.	Hyperalgesia 01/01/2009 - "In the two models of permanent pain tested, JN403 produces a significant reversal of mechanical hyperalgesia. "
4.	Epilepsy (Aura) 01/01/2009 - "The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain."
5.	Dementia (Dementias) 05/18/2010 - "The higher receptor specificity for JN403 could be important for the treatment of alpha7-related disorders, including dementias, pain-related ailments, depression, anxiety, and wound healing."

Related Drugs and Biologics

1.	alpha7 Nicotinic Acetylcholine Receptor