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SJA-95

a heptaene polyene macrolide antibiotic produced by the Streptomyces sp. strain S24

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        SJA-95: 3
- Lactones: 1549
  - Macrolides: 4391
    - SJA-95: 3
  - Polyketides: 231
    - Macrolides: 4391
      - SJA-95: 3
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - SJA-95: 3

Experts

1.	Desai, Sandhya K: 3 articles (12/2011 - 01/2008)
2.	Naik, Suresh R: 3 articles (12/2011 - 01/2008)
3.	Rahalkar, Prabhakar R: 1 article (12/2011)
4.	Thakare, Vishnu N: 1 article (12/2011)

Related Diseases

1.	Aspergillosis 05/01/2009 - "SJA-95, both in aspergillosis and cryptococcosis, progressively prolonged the survival time and decreased the fungal loads in vital organs respectively. " 05/01/2009 - "The purpose of this research was to evaluate the chemotherapeutic activity of a new heptaene polyene macrolide antibiotic (SJA-95) and liposomal incorporated SJA-95 (lip. SJA-95) in a mouse model of aspergillosis and cryptococcosis respectively. " 12/30/2011 - "New polyene macrolide antibiotic SJA-95 in free as well as liposomal (lip.) forms, with and without interferon-γ (IFN-γ) was studied in mice model of aspergillosis using biological and biochemical parameters viz. "
2.	Mycoses (Diseases, Fungus) 05/01/2009 - "SJA-95 treatment results in prolonged survival time, effective microbiological clearance and reduced toxicity that might help to establish its usefulness as a chemotherapeutic agent in systemic fungal infections with fewer adverse reactions."
3.	Cryptococcosis 05/01/2009 - "SJA-95, both in aspergillosis and cryptococcosis, progressively prolonged the survival time and decreased the fungal loads in vital organs respectively. " 05/01/2009 - "The purpose of this research was to evaluate the chemotherapeutic activity of a new heptaene polyene macrolide antibiotic (SJA-95) and liposomal incorporated SJA-95 (lip. SJA-95) in a mouse model of aspergillosis and cryptococcosis respectively. "
4.	Candidiasis (Moniliasis) 01/01/2008 - "The present results clearly indicated that Lip SJA-95 treatment led to prolonged survival time, effective microbiological clearance, and reduced toxicity in the mice model of Candidiasis." 01/01/2008 - "Lip SJA-95 treatment in experimental mice model of Candidiasis showed increased survival and reduced fungal loads in various organs. "

Related Drugs and Biologics

1.	Macrolides
2.	Anti-Bacterial Agents (Antibiotics)
3.	Interferons