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olamkicept

derived from gp130 and IgG1-Fc
Also Known As:
Sgp130Fc protein
Networked: 12 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Garbers, Christoph: 4 articles (01/2022 - 06/2011)
2. Rose-John, Stefan: 4 articles (01/2022 - 06/2011)
3. Scheller, Jürgen: 3 articles (12/2021 - 06/2011)
4. Lokau, Juliane: 2 articles (01/2022 - 01/2021)
5. Magro, Giuseppe: 2 articles (01/2022 - 01/2022)
6. Rosenstiel, Philip: 2 articles (01/2022 - 01/2021)
7. Schreiber, Stefan: 2 articles (01/2022 - 01/2021)
8. Waetzig, Georg H: 2 articles (01/2022 - 01/2021)
9. Grote, Karsten: 1 article (01/2022)
10. Laudes, Matthias: 1 article (01/2022)

Related Diseases

1. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/01/2022 - "Olamkicept, a highly selective IL-6 trans-signaling blocker has shown to be efficacious and safe in clinical trials involving patients with inflammatory bowel disease, another condition for which IL-6 trans-signaling is the mediating mechanism. "
01/01/2021 - "Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease."
10/01/2023 - "The first selective inhibitor of IL-6 trans-signalling, sgp130, has shown therapeutic potential in various preclinical models of disease and olamkicept, a sgp130Fc variant, had promising results in phase II clinical studies for inflammatory bowel disease. "
06/01/2011 - "We used recombinant sgp130Fc protein and recently generated transgenic mice expressing high levels of sgp130Fc to discriminate between classic and trans-signaling in vivo, and demonstrated that IL-6 trans-signaling is critically involved in generation and maintenance of several inflammatory and autoimmune diseases including chronic inflammatory bowel disease, rheumatoid arthritis, peritonitis and asthma, as well as inflammation-induced colon cancer."
02/01/2014 - "Using the sgp130Fc protein or sgp130Fc transgenic mice we demonstrate in models of inflammatory bowel disease, peritonitis, rheumatoid arthritis, atherosclerosis pancreatitis, colon cancer, ovarian cancer and pancreatic cancer, that IL-6 trans-signaling via the soluble IL-6R is the crucial step in the development and the progression of the disease. "
2. Cognitive Dysfunction
3. Alzheimer Disease (Alzheimer's Disease)
4. Neuromyelitis Optica (Devic's Disease)
5. Ulcerative Colitis

Related Drugs and Biologics

1. Interleukin-6 (Interleukin 6)
2. Cytokine Receptor gp130
3. Proteins (Proteins, Gene)
4. Interleukin-11 (Interleukin 11)
5. LDL Receptors (LDL Receptor)
6. LDL Cholesterol
7. LDL Lipoproteins (beta Lipoproteins)
8. Lipoproteins (Lipoprotein)
9. Cholesterol
10. Bilirubin

Related Therapies and Procedures

1. Therapeutics