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guttiferone K

antiproliferative compound of Rheedia calcicola from the Madagascar rain forest; structure in first source

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Benzophenones: 60
    - guttiferone K: 7
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzophenones: 60
        guttiferone K: 7

Experts

1.	Xu, Hongxi: 3 articles (01/2020 - 09/2015)
2.	Tan, Hongsheng: 2 articles (01/2020 - 09/2015)
3.	Fu, Yan: 1 article (01/2020)
4.	He, Weigang: 1 article (01/2020)
5.	Jiang, Xin: 1 article (01/2020)
6.	Li, Yinhong: 1 article (01/2020)
7.	Sun, Jinxia: 1 article (01/2020)
8.	Zhang, Qingwen: 1 article (01/2020)
9.	Boonyong, Cherdsak: 1 article (04/2017)
10.	Jianmongkol, Suree: 1 article (04/2017)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "The present study showed that Guttiferone K, isolated from Garcinia yunnanensis, could significantly inhibit Mtb-induced inflammation in RAW264.7 and primary peritoneal macrophages. " 01/01/2020 - "Thus, Guttiferone K possesses significant anti-inflammatory effect, alleviating Mtb-induced inflammation with an underlying mechanism that targeting on the TLR/IRAK-1 pathway and inhibiting the downstream NF-κB and Akt/mTOR signaling pathways. "
2.	Colonic Neoplasms (Colon Cancer) 02/01/2013 - "In this study, the anticancer effects and mechanisms of guttiferone K (GUTK), a novel polyprenylated acylphloroglucinol derivative isolated from Garcinia cowa Roxb., were examined for its development as a novel drug targeting colon cancer. " 02/01/2013 - "Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0) /G(1) cell cycle arrest and apoptosis."
3.	Neoplasms (Cancer) 09/15/2015 - "Through a screen designed to identify autophagic regulators from a library of natural compounds, we found that Guttiferone K (GUTK) can activate autophagy in several cancer cell lines. " 09/15/2015 - "Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death." 04/15/2017 - "Three new phytochemicals including two benzophenones, guttiferone K (GK) and oblongifolin C (OC), and a xanthone, isojacaruebin (ISO), are potential anti-cancer agents. "
4.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2017 - "Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro."
5.	Tuberculosis (Tuberculoses) 01/01/2020 - "Together, Guttiferone K can be an anti-inflammatory agent candidate for the design of new adjunct HDT drugs fighting against tuberculosis."

Related Drugs and Biologics

1.	oblongifolin C
2.	Phytochemicals
3.	Profilins (Profilin)
4.	Benzophenones
5.	Anti-Inflammatory Agents (Anti-Inflammatories)
6.	xanthone