MMP-9-hemopexin

recombinant MMP-9-PEX has an inhibitory effect on migration and adhesion of colorectal carcinoma cells

Also Known As:

MMP-9-PEX

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Hemopexin: 349
      - MMP-9-hemopexin: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        Matrix Metalloproteinases: 22164
        Secreted Matrix Metalloproteinases: 16
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4
        Collagenases: 4002
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4
        Gelatinases: 1359
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        Matrix Metalloproteinases: 22164
        Secreted Matrix Metalloproteinases: 16
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4
        Collagenases: 4002
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4
        Gelatinases: 1359
        Matrix Metalloproteinase 9: 4977
        MMP-9-hemopexin: 4

Experts

1.	Ezhilarasan, Ravesanker: 1 article (01/2009)
2.	Gujrati, Meena: 1 article (01/2009)
3.	Jadhav, Unmesh: 1 article (01/2009)
4.	Mohanam, Indra: 1 article (01/2009)
5.	Mohanam, Sanjeeva: 1 article (01/2009)
6.	Rao, Jasti S: 1 article (01/2009)
7.	Campana, W Marie: 1 article (11/2008)
8.	Gaultier, Alban: 1 article (11/2008)
9.	Gonias, Steven L: 1 article (11/2008)
10.	Inoue, Gen: 1 article (11/2008)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 04/01/2007 - "In the present study it was examined whether recombinant MMP-9-PEX has an inhibitory effect on migration and adhesion of colorectal carcinoma cells. " 04/01/2007 - "Since migration and adhesion of metastatic colorectal carcinoma cells were reduced by MMP-9-PEX, this recombinant MMP-9 antagonist might be of therapeutical interest." 04/01/2007 - "MMP-9-hemopexin domain hampers adhesion and migration of colorectal cancer cells."
2.	Neoplasms (Cancer) 01/15/2009 - "A significant tumor growth inhibition was observed in intracranial implants of MMP-9-PEX stable transfectants in nude mice with attenuation of CD31 and MMP-9 protein expression. " 01/15/2009 - "To assess the potential of the MMP-9-PEX domain to interfere with tumor progression, we stably transfected human glioblastoma cells with an expression vector containing a cDNA sequence of the MMP-9-PEX. "
3.	Melanoma (Melanoma, Malignant) 12/27/2002 - "In Boyden chamber experiments the recombinant MMP-9-PEX was able to inhibit the invasion of melanoma cells secreting high amounts of MMP-9 in a dose-dependent manner. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/15/2009 - "These results demonstrate that MMP-9-PEX inhibits angiogenic features of endothelial cells and retards intracranial glioblastoma growth." 01/15/2009 - "We assessed how secretion of MMP-9-PEX by glioblastoma cells affects angiogenic capabilities of human microvascular endothelial cells (HMECs) in vitro. " 01/15/2009 - "To assess the potential of the MMP-9-PEX domain to interfere with tumor progression, we stably transfected human glioblastoma cells with an expression vector containing a cDNA sequence of the MMP-9-PEX. "
5.	Crush Injuries 11/05/2008 - "Injection of MMP-9-PEX into sciatic nerves, 24 h after crush injury, robustly increased phosphorylation of ERK1/2 and Akt. "

Related Drugs and Biologics

1.	Complementary DNA (cDNA)
2.	Proteins (Proteins, Gene)