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NSC 644221

is a HIF-1 inhibitor with potential for use as both an analytic tool and a therapeutic agent

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cardellina, John H: 1 article (02/2007)
2.	Creighton-Gutteridge, Mark: 1 article (02/2007)
3.	Denny, William A: 1 article (02/2007)
4.	Hite, Karen: 1 article (02/2007)
5.	Melillo, Giovanni: 1 article (02/2007)
6.	Rapisarda, Annamaria: 1 article (02/2007)
7.	Shoemaker, Robert H: 1 article (02/2007)
8.	Stephen, Andrew G: 1 article (02/2007)
9.	Uranchimeg, Badarch: 1 article (02/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2007 - "Furthermore, although NSC 644221 induced p21 expression, gammaH2A.X, and G2-M arrest in the majority of cell lines tested, it only inhibited HIF-1alpha in a distinct subset of cells, raising the possibility of pathway-specific "resistance" to HIF-1 inhibition in cancer cells. "
2.	Hypoxia (Hypoxemia) 02/01/2007 - "Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Type II DNA Topoisomerases (Topoisomerase II)