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BAY 60-6583

structure in first source

Also Known As:

2-((6-amino-3,5-dicyano-4-(4-(cyclopropylmethoxy)phenyl)pyridin-2-yl)sulfanyl)acetamide; BAY-60-6583; BAY60-6583

Networked: 29 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - BAY 60-6583: 29
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - BAY 60-6583: 29

Experts

1.	Cohen, Michael V: 4 articles (05/2011 - 09/2007)
2.	Downey, James M: 4 articles (05/2011 - 09/2007)
3.	Miele, Lucio: 3 articles (09/2016 - 12/2013)
4.	Morello, Silvana: 3 articles (09/2016 - 12/2013)
5.	Pinto, Aldo: 3 articles (09/2016 - 12/2013)
6.	Eltzschig, Holger K: 3 articles (08/2015 - 06/2008)
7.	Krieg, Thomas: 3 articles (03/2013 - 10/2010)
8.	Methner, Carmen: 3 articles (03/2013 - 10/2010)
9.	Eckle, Tobias: 2 articles (01/2020 - 06/2008)
10.	French, Brent A: 2 articles (12/2018 - 01/2015)

Related Diseases

1.	Ischemia 01/01/2020 - "Two days after ischemia BAY60-6583 reduced blood cell infiltration in the ischemic cortex. " 01/01/2020 - "Seven days after ischemia BAY60-6583 reduced significantly the ischemic brain damage in cortex and striatum, counteracted ischemia-induced neuronal death, reduced microglia activation and astrocytes alteration. " 12/01/2018 - "BAY 60-6583, an A2BAR agonist, was injected by i.v. 15 min before ischemia. " 01/01/2020 - "Aim of this work was to verify whether chronic administration of the A2B agonist, BAY60-6583 (0.1 mg/kg i.p., twice/day), starting 4 h after focal ischemia induced by transient (1 h) Middle Cerebral Artery occlusion (tMCAo) in the rat, was protective after the ischemic insult. " 06/24/2008 - "In accordance, the A2BAR-antagonist PSB1115 blocked renal protection by IP, while treatment with the selective A2BAR-agonist BAY 60-6583 dramatically improved renal function and histology following ischemia alone. "
2.	Lung Injury 08/15/2015 - "Indeed, aerosolized BAY 60-6583 treatment was associated with attenuated pulmonary edema, improved histologic lung injury, and dampened lung inflammation. "
3.	Pulmonary Edema 08/15/2015 - "Indeed, aerosolized BAY 60-6583 treatment was associated with attenuated pulmonary edema, improved histologic lung injury, and dampened lung inflammation. "
4.	Pneumonia (Pneumonitis) 08/15/2015 - "Indeed, aerosolized BAY 60-6583 treatment was associated with attenuated pulmonary edema, improved histologic lung injury, and dampened lung inflammation. "
5.	Melanoma (Melanoma, Malignant) 12/01/2013 - "This study first shows that melanoma-bearing mice treated with Bay 60-6583, a selective A2bR agonist, had increased melanoma growth. " 09/27/2016 - "Interestingly, melanoma growth in mice receiving Bay60-6583 was attenuated by inhibition of the CXCL12/CXCR4 pathway with AMD3100. " 09/27/2016 - "Similar results were obtained under hypoxic conditions in skin-derived fibroblasts, which responded to Bay60-6583 in an A2BR-dependent manner, by stimulating pERK1/2. FGF2 produced by Bay60-6583-treated fibroblasts directly enhanced the proliferation of melanoma cells. " 09/27/2016 - "Treatment of melanoma-associated fibroblasts with the A2BR agonist Bay60-6583 enhanced CXCL12 and FGF2 expression. "

Related Drugs and Biologics

1.	1-propyl-8-(4-sulfophenyl)xanthine
2.	Adenosine A2B Receptor
3.	Ligands
4.	acetamide
5.	Phosphodiesterase 5 Inhibitors
6.	Therapeutic Uses
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Adenosine-5'-(N-ethylcarboxamide) (NECA)
9.	Purinergic P1 Receptors (Adenosine Receptor)
10.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)

Related Therapies and Procedures

1.	Ischemic Postconditioning