HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1-propyl-8-(4-sulfophenyl)xanthine

Also Known As:

1-propyl-8-p-sulfophenylxanthine; PSB 1115; PSB-1115; PSB1115

Networked: 14 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - 1-propyl-8-(4-sulfophenyl)xanthine: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        1-propyl-8-(4-sulfophenyl)xanthine: 14

Experts

1.	Miele, Lucio: 3 articles (09/2016 - 12/2013)
2.	Morello, Silvana: 3 articles (09/2016 - 12/2013)
3.	Pinto, Aldo: 3 articles (09/2016 - 12/2013)
4.	Eltzschig, Holger K: 3 articles (04/2009 - 02/2008)
5.	Porta, Amalia: 2 articles (09/2016 - 09/2015)
6.	Sorrentino, Claudia: 2 articles (09/2016 - 09/2015)
7.	Müller, Christa E: 2 articles (03/2010 - 03/2008)
8.	Eckle, Tobias: 2 articles (06/2008 - 02/2008)
9.	Grenz, Almut: 2 articles (06/2008 - 02/2008)
10.	Chen, Yan-Xiang: 1 article (01/2020)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "Our results showed that the inhibition of A2BR PSB1115 improved intestinal injury and inflammation in newborn NEC rats. " 03/01/2008 - "In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. " 03/01/2010 - "In this study, we examined the effect of the adenosine A(2A) receptor agonist CGS 21680 and the A(2B)R antagonist PSB-1115 on acute inflammation induced experimentally by 2,4,6-trinitrobenzenesulfonic acid (TNBS) on rat ileum/jejunum preparations. "
2.	Ischemia 06/24/2008 - "In accordance, the A2BAR-antagonist PSB1115 blocked renal protection by IP, while treatment with the selective A2BAR-agonist BAY 60-6583 dramatically improved renal function and histology following ischemia alone. "
3.	Hypoxia (Hypoxemia) 02/15/2008 - "Further studies in wild type mice revealed that the selective A2BAR antagonist PSB1115 resulted in profound increases in hypoxia-associated vascular leakage while A2BAR agonist (BAY60-6583 [2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)-. " 01/01/2014 - "The A2BAR antagonist, PSB1115, significantly increased tight junction protein expression after intestinal I/R or acute hypoxia conditions. "
4.	Hyperalgesia 03/01/2008 - "In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. "
5.	Neoplasms (Cancer) 09/29/2015 - "Pharmacological blockade of A2B receptor with PSB1115 significantly reduced tumor growth by inhibiting tumor angiogenesis and increasing T cells numbers within the tumor microenvironment. " 12/01/2013 - "These data suggest that the antitumor activity of PSB1115 relies on its ability to lower accumulation of tumor-infiltrating MDSCs and restore an efficient antitumor T cell response. " 09/27/2016 - "Here, we report that pharmacologic inhibition of A2BR with PSB1115, which inhibits tumor growth, decreased the number of fibroblast activation protein (FAP)-expressing cells in tumors in a mouse model of melanoma. "

Related Drugs and Biologics

1.	BAY 60-6583
2.	Adenosine A2A Receptor (Adenosine A2A Receptors)
3.	Purinergic P1 Receptor Antagonists
4.	Acids
5.	1- butyl- 8- (3- noradamantyl)- 3- (3- hydroxypropyl)xanthine
6.	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
7.	Tight Junction Proteins
8.	Adenosine A2B Receptor
9.	Interleukin-10 (Interleukin 10)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Lasers (Laser)