7-deaza-2'-C-methyladenosine

an antiviral agent

Also Known As:

7-DMA cpd; MK 0608; MK-0608; MK0608

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Tubercidin: 42
        7-deaza-2'-C-methyladenosine: 7
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Tubercidin: 42
      - 7-deaza-2'-C-methyladenosine: 7
  - Ribonucleosides: 49
    - Tubercidin: 42
      - 7-deaza-2'-C-methyladenosine: 7

Experts

1.	Kaptein, Suzanne J F: 3 articles (04/2019 - 01/2016)
2.	Neyts, Johan: 3 articles (04/2019 - 01/2016)
3.	Carroll, Steven S: 2 articles (02/2011 - 03/2009)
4.	Davies, Mary-Ellen: 2 articles (02/2011 - 03/2009)
5.	Graham, Donald: 2 articles (02/2011 - 03/2009)
6.	Handt, Larry: 2 articles (02/2011 - 03/2009)
7.	Hazuda, Daria: 2 articles (02/2011 - 03/2009)
8.	Koeplinger, Kenneth: 2 articles (02/2011 - 03/2009)
9.	MacCoss, Malcolm: 2 articles (02/2011 - 03/2009)
10.	Olsen, David B: 2 articles (02/2011 - 03/2009)

Related Diseases

1.	Zika Virus Infection 12/01/2016 - "In addition, the study suggested two nucleotide inhibitors (IDX-184 and MK0608) that may be tested as drugs against ZIKV infection. " 01/01/2018 - "Of three antiviral molecules that inhibit ZIKV infection in Vero cells, only 7-deaza-2'-C-methyladenosine (7DMA) inhibited ZIKV replication in hPSC-HLCs, while all drugs inhibited ZIKV infection in Huh7 cells. "
2.	Infections 01/01/2016 - "The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model." 01/01/2019 - "However, the antiviral effect of 7-deaza-2'-C-methyladenosine was absent or negligible when the treatment was started 8 days postinfection (i.e., at the time of extensive brain infection). " 02/01/2011 - "This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection."
3.	Disease Progression 01/01/2016 - "The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model." 01/01/2019 - "One representative of C2'-methylated nucleosides, 7-deaza-2'-C-methyladenosine, significantly protected WNV-infected mice from disease progression and mortality. "
4.	West Nile Fever 01/01/2019 - "Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection."
5.	Viremia 04/29/2019 - "Male AG129 mice infected with a ZIKV isolate from Suriname were treated with the nucleoside analog, 7-deaza-2'-C-methyladenosine (7DMA), that was previously shown to be efficacious in reducing ZIKV viremia and delaying ZIKV-induced disease in mice. "

Related Drugs and Biologics

1.	Nucleotides
2.	Nucleosides
3.	Antiviral Agents (Antivirals)
4.	Viral RNA
5.	DNA-Directed RNA Polymerases (RNA Polymerase)
6.	Protease Inhibitors (Protease Inhibitor)
7.	vaniprevir

Related Therapies and Procedures

1.	Intravenous Administration